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DNA Methylation Profiling Reveals Novel Biomarkers and Important Roles for DNA Methyltransferases in Prostate Cancer
Candidate gene based studies have identified a handful of aberrant CpG DNA methylation events in prostate cancer (Brooks et al. 1998; Yegnasubramanian et al. 2004). However, large scale DNA methylation profiles have not been examined for normal prostates or prostate tumors. Additionally, the mechanisms behind these DNA methylation alterations are unknown. In this thesis, I describe the results of my efforts to better understand these previously unexplored areas of biology. For the study presented in this thesis, I quantitatively profiled 95 primary prostate tumors and 86 healthy prostate tissue samples for their DNA methylation levels at 26,333 CpGs representing 14,104 gene promoters by using the Illumina HumanMethylation27 platform. When the profiles of the prostate tissue samples were compared, I observed a substantial number of tumor-specific DNA methylation alterations. A 2-class Significance Analysis of this dataset revealed 5,912 CpG sites with increased DNA methylation and 2,151 CpG sites with decreased DNA methylation in tumors (FDR
The Little Book of Tom. Military Men
Stand at attention with this pocket-sized army of free, proud, masculine fantasy men committed to pleasure and male camaraderie. With multi-panel comics and single-panel drawings and paintings, as well as personal photographs, sketches, and reference images, The Little Book of Tom: Military Men celebrates the artist's most iconic vision of...
Hormone Therapy and Castration Resistance of Prostate Cancer
This comprehensive reference expounds the current state of hormone therapy and castration resistance of prostate cancer (PCa). Previously, the incidence of PCa in Asian countries was relatively low, but it has been increasing dramatically in recent years. Although most of the new cases are diagnosed in early stages, a significant proportion of patients receive hormone therapy for metastatic disease or for relapse after local treatment. Thus the situation has gradually changed toward earlier and longer use of hormone therapy. The malignancy finally forms castration-resistant prostate cancer (CRPC) despite the lack of testicular androgen. With advances in understanding of the molecular basis o...
Artificial Intelligence Research and Development
Artificial intelligence has become an indispensible part of our lives in recent years, affecting all aspects from business and leisure to transport and health care. This book presents the proceedings of the 23rd edition of the International Conference of the Catalan Association for Artificial Intelligence (CCIA), an annual event that serves as a meeting point for researchers in Artificial Intelligence in the area of the Catalan speaking territories and from around the world. The 2021 edition was held online as a virtual conference from 20 - 22 October 2021 due to the COVID-19 pandemic. The book contains 42 long papers and 9 short papers, carefully reviewed and selected. The papers cover all ...
Art and Cosmotechnics
In light of current discourses on AI and robotics, what do the various experiences of art contribute to the rethinking of technology today? Art and Cosmotechnics addresses the challenge of technology to the existence of art and traditional thought, especially in light of current discourses on artificial intelligence and robotics. It carries out an attempt on the cosmotechnics of Chinese landscape painting in order to address this question, and further asks: What is the significance of shanshui (mountain and water) in face of the new challenges brought about by the current technological transformation? Thinking art and cosmotechnics together is an attempt to look into the varieties of experiences of art and to ask what these experiences might contribute to the rethinking of technology today.
Multivalency
Connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field. Multivalency: Concepts, Research & Applications is divided into three parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their st...
The Oxford Handbook of Names and Naming
In this handbook, scholars from around the world offer an up-to-date account of the state of the art in different areas of onomastics, in a format that is both useful to specialists in related fields and accessible to the general reader. Since Ancient Greece, names have been regarded as central to the study of language, and this has continued to be a major theme of both philosophical and linguistic enquiry throughout the history of Western thought. The investigation of name origins is more recent, as is the study of names in literature. Relatively new is the study of names in society, which draws on techniques from sociolinguistics and has gradually been gathering momentum over the last few ...
Prannie Rhatigan's Irish Seaweed Kitchen
Irish seaboard lore, recipes old & new, nutritional information & personal anecdote combine with the faintest hint of nostalgia in this refreshingly original mix of common sense & practical cookery.
Skin Cancer
Skin Cancer: A Practical Approach presents a comprehensive and up to date overview on skin cancer. With an emphasis on practical aspects that will set the basis for guidelines of treatment, the volume presents different diagnostic tools to help physicians obtain the proper diagnosis. Written by a worldwide base of experts selected on their recognized expertise on the different themes discussed, Skin Cancer: A Practical Approach is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, dermatologists, general surgeons, and veterinary oncologists
Obesity
This comprehensive textbook addresses one of the major public health concerns of our era – obesity. Clearly and simply, Obesity: science to practice provides a balanced, coherent account of obesity: how to define and measure it, its epidemiology, the physiological basis, associated diseases, how to assess, manage and treat it, and also strategies for prevention. The book is generously illustrated, including graphs and flow charts for easy reference. The chapters cite key references so that interested readers may pursue a given topic in more detail. Well presented and thoroughly edited by one of the leading experts in the field, this is the textbook of choice for anyone working in obesity.
