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DNA Methylation Profiling Reveals Novel Biomarkers and Important Roles for DNA Methyltransferases in Prostate Cancer
Candidate gene based studies have identified a handful of aberrant CpG DNA methylation events in prostate cancer (Brooks et al. 1998; Yegnasubramanian et al. 2004). However, large scale DNA methylation profiles have not been examined for normal prostates or prostate tumors. Additionally, the mechanisms behind these DNA methylation alterations are unknown. In this thesis, I describe the results of my efforts to better understand these previously unexplored areas of biology. For the study presented in this thesis, I quantitatively profiled 95 primary prostate tumors and 86 healthy prostate tissue samples for their DNA methylation levels at 26,333 CpGs representing 14,104 gene promoters by using the Illumina HumanMethylation27 platform. When the profiles of the prostate tissue samples were compared, I observed a substantial number of tumor-specific DNA methylation alterations. A 2-class Significance Analysis of this dataset revealed 5,912 CpG sites with increased DNA methylation and 2,151 CpG sites with decreased DNA methylation in tumors (FDR
Insight Yoga
Acclaimed yoga and meditation teacher Sarah Powers is known and loved for her unique approach—Insight Yoga—which combines traditional yoga with the meridians of Chinese medicine, as well as Buddhist meditation. Using Yin (passive) and Yang (dynamic) poses, she demonstrates a series of different yoga sequences that bring benefit to organs, muscles, joints, and tendons—as well as the mind. She also provides a foundational explanation of traditional Chinese medicine theory and mindfulness meditation instruction. Sarah Powers brings us on an inspiring journey inward, and shows the path for cultivating a lasting relationship with yoga that cultivates and strengthens our physical well-being and our mental and emotional clarity.
Menopause Yoga
Bringing together western medical science and eastern wellbeing for menopause education, this book helps yoga teachers develop their understanding of menopause and women's health as well as support their students. Petra Coveney - creator of Menopause YogaTM - shares yoga, breath and meditation practices, poses, and CBT and self-enquiry methods to manage menopause symptoms. Her book helps to educate and empower women going through menopause, allowing them to embrace it as an opportunity for self-growth. It includes three main yoga sequences that focus on managing specific groups of symptoms, as well as additional sequences for sleep, menorage, and osteopenia. This is the dedicated resource for yoga teachers who want to teach Menopause YogaTM, with four detailed 90-minute class plans also available to download. Underpinned by research and 20 years of teaching experience, Menopause Yoga helps those on their journey from peri-menopause to post-menopause to help them welcome the changes in their minds, bodies and emotions as they enter the next stage in their lives.
The Little Book of Tom. Military Men
Stand at attention with this pocket-sized army of free, proud, masculine fantasy men committed to pleasure and male camaraderie. With multi-panel comics and single-panel drawings and paintings, as well as personal photographs, sketches, and reference images, The Little Book of Tom: Military Men celebrates the artist's most iconic vision of...
May I Be Happy
For all her wisdom as a teacher, Cyndi Lee understood intuitively that she still had a lot to learn. In spite of her success in physically demanding professions - dancer, choreographer, and yoga teacher - Lee was caught in a lifelong cycle of repetitive self-judgment about her body. Instead of the radical contentment expected in international yoga teachers, she realised that hating her body was a form of suffering, which was infecting her closest relationships - including her relationship to herself. Inspired by the honesty and vulnerability of her students, Lee embarked on a journey of self-discovery that led her outward - from the sacred sites of the parched Indian countryside to the cente...
Multivalency
Connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field. Multivalency: Concepts, Research & Applications is divided into three parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their st...
Artificial Intelligence Research and Development
Artificial intelligence has become an indispensible part of our lives in recent years, affecting all aspects from business and leisure to transport and health care. This book presents the proceedings of the 23rd edition of the International Conference of the Catalan Association for Artificial Intelligence (CCIA), an annual event that serves as a meeting point for researchers in Artificial Intelligence in the area of the Catalan speaking territories and from around the world. The 2021 edition was held online as a virtual conference from 20 - 22 October 2021 due to the COVID-19 pandemic. The book contains 42 long papers and 9 short papers, carefully reviewed and selected. The papers cover all ...
The Oxford Handbook of Names and Naming
In this handbook, scholars from around the world offer an up-to-date account of the state of the art in different areas of onomastics, in a format that is both useful to specialists in related fields and accessible to the general reader. Since Ancient Greece, names have been regarded as central to the study of language, and this has continued to be a major theme of both philosophical and linguistic enquiry throughout the history of Western thought. The investigation of name origins is more recent, as is the study of names in literature. Relatively new is the study of names in society, which draws on techniques from sociolinguistics and has gradually been gathering momentum over the last few ...
Internet Addiction Test (IAT)
While the Internet is a relatively new technology, that has impacted the world, and provided many benefits, it has also had negative ramifications. Individuals unable to control their use are jeopardizing school, employment and relationships. The concept of “Internet Addiction” is used to explain uncontrollable, damaging use of technology. It is characterized as an impulse control disorder, comparable to pathological gambling, because of overlapping diagnostic criteria and symptomatology. Based on these studies, the IAT was constructed to capture the problematic behavior associated with compulsive use of technology, including online porn, internet gambling and compulsive use of online ga...
