Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap!
The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.
The Alzheimer's Disease Challenge
Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.
Drosophila: A Toolbox for the Study of Neurodegenerative Disease
Drosophila gives an overview of the ways in which Drosophila is currently being used as a model organism to further our understanding of a spectrum of human neurological diseases. Each chapter is written by respected researchers and gives an excellent account of the subject that is suitable for postgraduate and postdoctoral researchers.
Folding for the Synapse
Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an isolated moiety or part of a protein complex. This book will introduce both important concepts of folding machineries and give examples of the biological relevance of further chaperone functions.
The Alzheimer Conundrum
Why our approaches to Alzheimer's and dementia are problematic and contradictory Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer’s disease through early detection of pre-symptomatic biological changes in healthy individuals. Based on a meticulous account of the history of Alzheimer’s disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure.
Untangling the Role of Tau in Physiology and Pathology
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Tau oligomers
Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, t...
Köszvény
Mi a közös az elhízásban, az inzulinrezisztenciában, a májelzsírosodásban, a magas vérnyomásban, a kardiovaszkuláris kórképekben, a sztrókban, a neurológiai zavarokban és a korai elhalálozásban? Az, hogy mindegyik összefügg a megemelkedett húgysavszinttel. Az elismert tudományos folyóiratokban és más kiadványokban ma már rengeteg bizonyítékot találunk arra, hogy a magasabb húgysavszint számos egészségügyi probléma forrása, de a mindennapi orvoslásban még kevéssé figyelnek erre az összefüggésre. Ez azért különösen riasztó, mert az emberek túlnyomó többsége nem is tudja, hogy megemelkedett a húgysavszintje, amitől számos krónikus, időve...
질병 정복의 꿈, 바이오 사이언스
과학 분야 스테디셀러 『질병 정복의 꿈, 바이오 사이언스』 개정판으로 출간! 21세기는 바이오 시대! 인류, 질병에 도전하고 건강을 욕망하다 미국의 열정적이고 치열한 바이오 의약품 연구가 전 세계적으로 주목받고 있는 가운데, 비만 치료제와 mRNA 백신을 중심으로 새로운 의약품 시장의 혁명을 불러일으키고 있다. 2019년 12월 전 세계를 강타한 코로나19의 대유행은 과학자들에게 새로운 기회를 제공하였으며, 코로나19 바이러스와의 전쟁에서 승리하기 위해 과학자들은 세계 최초로 mRNA 백신을 상용화했다. 코로나19 mRNA 백신...
