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The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation
The neurodegenerative disorders such as Parkinson’s disease (PD) or Alzheimer’s disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the diseases. The lack of a therapeutic approach is also due to a lack of an early diagnosis. This Research Topic describes a new target that is involved in the firs step of these disorders and that can be useful for the treatment and the diagnosis of such pathologies: the cannabinoid receptor subtype 2 or CB2R. Indeed, CB2R is overexpressed in reactive microglia and activated astrocytes during neuroinflammation and thus their detection by PET probes can be an easily strategy for an early diagnosis of neurodegeneration. Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies. Therefore, the aim of this Research Topic is to show the great potential of CB2R ligands for the development of new tools/drugs for both the therapy and the diagnosis of neurodegeneration.
Foucault's Philosophy of Art
Offers the first complete examination of Foucault's reflections on visual art, leading to new readings of his major texts.
Wildlife Review
None
State-of-the-Art Sensors Technology in Spain 2017 Volume 2
This book is a printed edition of the Special Issue "State-of-the-Art Sensors Technology in Spain 2017" that was published in Sensors
Das Rätsel des Lammes
Dieses Buch basiert auf einer ungewöhnlichen Entdeckung: Das berühmteste und zugleich geheimnisvollste Kunstwerk des Spätmittelalters, der Genter Altar von van Eyck, zeigt in seiner Komposition den Grundriss einer alten Kirche in Spanien aus der Zeit der Kreuzzüge. Der Autor erläutert allgemein verständlich seine Entdeckung und ihre möglichen Deutungen, sowie das Kunstwerk als solches. Dann lädt er Sie, die Leserinnen und Leser dieses Buches, ein, sich selbst auf die Suche nach dem letzten Stück in diesem Puzzle zu begeben. 168 Seiten, 87 Abbildungen
Understanding Foucault, Understanding Modernism
Michel Foucault continues to be regarded as one of the most essential thinkers of the twentieth century. A brilliantly evocative writer and conceptual creator, his influence is clearly discernible today across nearly every discipline-philosophy and history, certainly, as well as literary and critical theory, religious and social studies, and the arts. This volume exploits Foucault's insistent blurring of the self-imposed limits formed by the disciplines, with each author in this volume discovering in Foucault's work a model useful for challenging not only these divisions but developing a more fundamental interrogation of modernism. Foucault himself saw the calling into question of modernism ...
To the Royal Crown Restored
A documentary account of the resettlement of New Mexico composed of journals and official government records from the late 17th century.
Lady Gregory and Irish National Theatre
This book is the first comprehensive critical assessment of the aesthetic and social ideals of Lady Augusta Gregory, founder, patron, director, and dramatist of the Abbey Theatre in Dublin. It elaborates on her distinctive vision of the social role of a National Theatre in Ireland, especially in relation to the various reform movements of her age: the Pre-Raphaelite Movement, the Co-operative Movement, and the Home Industries Movement. It illustrates the impact of John Ruskin on the aesthetic and social ideals of Lady Gregory and her circle that included Horace Plunkett, George Russell, John Millington Synge, William Butler Yeats, and George Bernard Shaw. All of these friends visited the celebrated Gregory residence of Coole Park in Country Galway, most famously Yeats. The study thus provides a pioneering evaluation of Ruskin’s immense influence on artistic, social, and political discourse in Ireland in the late nineteenth and early twentieth century.
