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Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis
Abstract: The MRZ reaction (MRZR) comprises the three antibody indices (AIs) against measles, rubella, and varicella zoster virus, reflecting an intrathecal polyspecific B cell response highly specific for multiple sclerosis (MS). Thus, MRZR can be used to confirm a diagnosis of primary progressive MS (PPMS) but its pathophysiological and wider clinical relevance is unclear. This study aimed to investigate whether PPMS patients with a positive MRZR (MRZR+) differ from those with a negative MRZR (MRZR-) according to cerebrospinal fluid (CSF) biomarkers of B cell activity, neuroaxonal damage or glial activity, and clinical features. (1) Methods: In a multicenter PPMS cohort (n = 81) with known...
Cerebrospinal Fluid in Neurologic Disorders
Cerebrospinal Fluid in Neurologic Disorders, Volume 146 provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker. The second part addresses the main purpose of the volume, describing CSF from a research perspective in context with the most important diagnostic entities in neurology. The book's authors provide insight into the current understanding of CSF changes in these various conditions and what it tells us about the nature of neurological diseases. Furthermore, methodological aspects are discussed, as are shortcomings that need to be addressed. Finally, the book provides an outlook for potential directions that can be explored to improve the various aspects of CSF research with the ultimate goal of being incorporated in clinical practice. Provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker Addresses relevant research in context with the most important diagnostic entities in neurology Edited by leading authors in CSF research from around the globe, presenting the broadest, most expert coverage available
The Unspoken Rules
Named one of 10 Best New Management Books for 2022 by Thinkers50 A Wall Street Journal Bestseller "...this guide provides readers with much more than just early careers advice; it can help everyone from interns to CEOs." — a Financial Times top title You've landed a job. Now what? No one tells you how to navigate your first day in a new role. No one tells you how to take ownership, manage expectations, or handle workplace politics. No one tells you how to get promoted. The answers to these professional unknowns lie in the unspoken rules—the certain ways of doing things that managers expect but don't explain and that top performers do but don't realize. The problem is, these rules aren't ...
Cerebrospinal Fluid in Clinical Neurology
The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identified. However, properly interpreting the test results requires a high level of expertise and cannot be achieved by just reporting on individual analytic values. This book covers essential aspects of cer...
Station Zero
After receiving a mysterious coded message, Zen Starling abandons his life of luxury and, with the help of sentient trains, goes in search of android Nova, who plans to reawaken the Railmaker.
An Elderly Lady Is Up to No Good
Maud is an irascible 88-year-old Swedish woman with no family, no friends, and... no qualms about a little murder. This funny, irreverent story collection by Helene Tursten, author of the Irene Huss investigations, features two-never-before translated stories that will keep you laughing all the way to the retirement home. Ever since her darling father's untimely death when she was only eighteen, Maud has lived in the family's spacious apartment in downtown Gothenburg rent-free, thanks to a minor clause in a hastily negotiated contract. That was how Maud learned that good things can come from tragedy. Now in her late eighties, Maud contents herself with traveling the world and surfing the net from the comfort of her father's ancient armchair. It's a solitary existence, and she likes it that way. Over the course of her adventures—or misadventures—this little bold lady will handle a crisis with a local celebrity who has her eyes on Maud's apartment, foil the engagement of her long-ago lover, and dispose of some pesky neighbors. But when the local authorities are called to investigate a dead body found in Maud's apartment, will Maud finally become a suspect?
