Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions
This book provides essential insights into designing a localized DNA circuit to promote the rate of desired hybridization reactions over undesired leak reactions in the bulk solution. The area of dynamic DNA nanotechnology, or DNA circuits, holds great promise as a highly programmable toolbox that can be used in various applications, including molecular computing and biomolecular detection. However, a key bottleneck is the recurring issue of circuit leakage. The assembly of the localized circuit is dynamically driven by the recognition of biomolecules – a different approach from most methods, which are based on a static DNA origami assembly. The design guidelines for individual reaction modules presented here, which focus on minimizing circuit leakage, are established through NUPACK simulation and tested experimentally – which will be useful for researchers interested in adapting the concepts for other contexts. In the closing section, the design concepts are successfully applied to the biomolecular sensing of a broad range of targets including the single nucleotide mutations, proteins, and cell surface receptors.
Land-Based and Marine Hazards
Causes of major disasters are many and diverse, and the risks associated with them endanger human lives, property, the environment, the economy, and even the country's political and social well-being. It is clear that, with rapid population growth, environmental degradation, climate change, poorly regulated industries, and continued economic uncertainty, the chances are that communities may become more vulnerable to disasters. The dramatic losses in recent years from volcanic eruptions, earthquakes and landslides, wildland fires, droughts and floods, cyclones and storm surges attest to the fact that we are still a long way from applying even the knowledge we have today to make communities sa...
China and Its People
None
