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Basic Orthopaedic Biomechanics & Mechano-biology
Biomaterials / Ahmed El-Ghannam and Paul Ducheyne -- Biomechanics of the spine / Ian A. F. Stokes and James C. Iatridis -- Biomechanics of fracture fixation and fracture healing / Lutz E. Claes and Keita Ito -- Biomechanics and preclinical testing of artificial joints: the hip / Rik Huiskes and Jan Stolk -- Biomechanics of total knee replacement designs / Peter S. Walker.
Mitochondrial Disorders
The concept of mitochondrial diseases originated in 1962 with the description by Luft and coworkers of a patient with nonthyroidal hypermetabolism due to loose coupling of oxidation and phosphorylation in muscle mitochondria. Over the following quarter of a century, thanks to W. King Engel's "ragged-red fibres" as convenient markers for mitochondrial pathology, numerous papers described clinical, morphological, and biochemical features of "mitochondrial myopathies." In 1988 the discovery of mutations in mitochondrial DNA led to an explosive expansion of research into mitochondrial disorders. Throughout the 1990s the rapid identification of multiple mitochondrial gene defects associated with ...
Microbial and Biotechnological Interventions in Bioremediation and Phytoremediation
The introduction of contaminants, due to rapid urbanisation and anthropogenic activities, into the environment causes unsteadiness, distress to the physico-chemical systems including living organisms, which possibly is threatening the dynamics of nature as well as the soil biology by producing certain xenobiotics. Hence, there is an immediate global demand for the diminution of such contaminants and xenobiotics which can otherwise adversely affect the living organisms. Some toxic xenobiotics include synthetic organochlorides such as polycyclic aromatic hydrocarbons (PAHs), and some fractions of crude oil and coal. The advancements in microbiology and biotechnology has lead to the launch of m...
Neurobiology of Huntington’s Disease
In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the fiel...
Mouse Models in the Study of Genetic Neurological Disorders
The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. As this volume goes to press, I am sure that additional mouse genes responsible for naturally occurring neurological disorders are being discovered and that many new transgenic and mutant mouse strains are being developed. Therefore, this volume should not be viewed as a c...
The Basal Ganglia VI
This volume represents the proceedings of the Sixth TriennialMeeting of the International Basal Ganglia Society, held in Brewster, Massachusetts from October 15-18, 1998. This volume focuses on thefunctions of the basal ganglia in health and disease and the neuralmechanisms that underpin these functions. This book is useful foranyone in the field of neuroscience, neuropharmacology, neurobiology, neuroanatomy and neurophysiology.
