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Role of Epigenetic Modifications on Diet-Induced Metabolic Diseases
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Interplay Between Diets, Microbiota, Bacterial Metabolites and Host for Intestinal Health and Disease
An interplay between the diet and the microbiota appears to regulate the host responses. It is now well acknowledged that the microbiota and their metabolites such as short chain fatty acids, bile acids, etc modulates the metabolic status, educates the host’s intestinal immune system, and protects the host against invading pathogens and injury. Concomitantly, environmental factors such as diets and dietary components play a major role in shaping the microbiota, thereby modulating the host immune and epithelial responses, and ultimately directing the individual’s health status. Disruption in any of these elements or their interactions have been linked to the development and progression of...
Metabolic-associated fatty liver disease, An Issue of Endocrinology and Metabolism Clinics of North America, E-Book
In this issue of Endocrinology and Metabolism Clinics of North America, guest editors Drs. Sherouk Fouda and Joseph M. Pappachan bring their considerable expertise to the topic of Metabolic Associated Fatty Liver Disease. Top experts address the various ways metabolic associated fatty liver disease is related to other conditions such as diabetes, sarcopenia, PCOS, and more, as well as the management of MAFLD and cardiovascular implications. - Contains 12 practice-oriented topics including obstructive sleep apnea and MAFLD; the interlink between MAFLD and polycystic ovary syndrome; pregnancy and MAFLD; MAFLD and gut microbiota; and more. - Provides in-depth clinical reviews of metabolic associated fatty liver disease, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Pediatric Obesity
Childhood obesity and its co-morbidities -- including type 2 diabetes, hypertension, dyslipidemia, sleep apnea, and fatty liver disease -- have seen striking increases in recent years. Despite a wealth of investigation, there is considerable controversy regarding the etiology of childhood obesity and the optimal approaches for prevention and treatment. Pediatric Obesity: Etiology, Pathogenesis, and Treatment addresses the controversy with a range of features that make it a unique resource for those who care for obese children and their families. Written from a perspective that is international in scope, the distinguished authors re-assess the roles of genetic and environmental factors in the pathogenesis of childhood obesity and critically review new studies of the effects of lifestyle, pharmacologic, and surgical interventions. The evidence-based approach of Pediatric Obesity: Etiology, Pathogenesis, and Treatment provides a comprehensive and invaluable guide for all healthcare providers concerned with the evaluation and care of children with nutritional and metabolic disease and with the societal implications of the obesity epidemic.
Global Perspectives on Childhood Obesity
Understanding the complex factors contributing to the growing childhood obesity epidemic is vital not only for the improved health of the world's future generations, but for the healthcare system. The impact of childhood obesity reaches beyond the individual family and into the public arenas of social systems and government policy and programs. Global Perspectives on Childhood Obesity explores these with an approach that considers the current state of childhood obesity around the world as well as future projections, the most highly cited factors contributing to childhood obesity, what it means for the future both for children and society, and suggestions for steps to address and potentially prevent childhood obesity. - This book will cover the multi-faceted factors contributing to the rapidly growing childhood obesity epidemic - The underlying causes and current status of rapidly growing obesity epidemic in children in the global scenario will be discussed - The strategies for childhood obesity prevention and treatment such as physical activity and exercise, personalized nutrition plans and school and community involvement will be presented
Community Series - Liver Fibrosis and MAFLD: from Molecular Aspects to Novel Pharmacological Strategies, Volume II
This Research Topic is the second volume of the Community Series, Liver Fibrosis and MAFLD: from Molecular Aspects to Novel Pharmacological Strategies. Please find the first Edition here. Metabolic disorders, such as obesity and type 2 diabetes mellitus, represent a critical health problem. This is mainly due to the economic cost of health services supporting the treatment for these patients of both primary and secondary disorder effects. Fatty liver damage associated with metabolic dysfunction is currently called Metabolic Associated Fatty Liver Disease (MAFLD), a new concept proposed in 2020, which affects a quarter of the population worldwide and is characterized by liver fat accumulation and all the repercussions that this may bring, such as inflammation, fibrosis, cirrhosis and in some cases, hepatocellular carcinoma.
Regulation by non-coding RNAs Volume 1
Printed Edition of the Special Issue Published in IJMS
Analysis of Chronic Diseases Progression Using Stochastic Modeling
This is a book that handles the non-alcoholic fatty liver disease from the bio-statistical point of view . The statistical method used is Continuous Time Markov Chains ( CTMCs) utilizing the MLE and quasi-Newton method to estimates the transition rate matrix , once obtained , the transition probability matrix can be estimated by exponentiation of this rate matrix. The transition probability matrix can also be obtained by solving forward Kolmogorov differential equations which yields more stable solution than the matrix exponentiation. The rate probability matrix can then be used to estimate the number of patients in each stage of the disease process as well as the life expectancy in each sta...
