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New Mechanisms for Anti-Cancer Drugs
Cancer is the second leading cause of death. Every year, many anticancer drug candidates are discovered and synthesized, but the major challenge lies in identifying, characterizing and evaluating their efficacy. The aim of this Research Topic, "New Mechanisms for Anti-Cancer Drugs" is to collect a group of publications focused on novel chemical compounds exhibiting new modes of actions and/or new target proteins to fulfill their cytotoxic activity on cancer cells. In this context, we will also be pleased to consider studies on drug repurposing, including approved, discontinued, and shelved drugs, when anti-cancer activity results from an unexpected mode of action.
Integrated Diagnostics and Biomarker Discovery in Endocrinology and Biomedical Sciences
Recent advancements and cost reduction in various omics technologies have provided us with a wealth of data at the molecular, cellular and organ levels. Other types of comprehensive data sets are also increasingly available at the individual, community and population levels. The integration of these different types of data are enabling multidisciplinary convergences in diagnostics and biomarker discovery in various biomedical fields to realize a more holistic, systems biology view of diseases. Such integrated approaches have also proven useful in the field of endocrinology, particularly in better understanding complex, heterogeneous diseases such as type 2 diabetes mellitus. For instance, researchers have combined genotyping data and RNA-sequencing data with glycomics and lipidomics to identify potential biomarkers in type 2 diabetes.
Diseases of the Salivary Glands
A large number of diseases affect salivary gland (SG) secretion through different mechanisms, leading to SG dysfunction and associated oral problems. The glands may suffer from viral, bacterial, and, albeit rarely, fungal infections, which may cause painful swelling or obstruction; they could also become the target of an autoimmune attack or may be affected by various benign and malignant tumors which consist of a heterogeneous group of lesions with complex clinical–pathological characteristics. The loss of normal SG function results in widespread deterioration of oral health. This book, entitled “Diseases of Salivary Glands”, provides an overview of recent advances in the field of SG disorders, focusing on the cellular and molecular mechanisms involved in the pathogenesis of SG diseases and on the most innovative investigation techniques that could help to preserve patients’ health, function, and quality of life.
Inner Voice
Witold Poplawski's independently formed poetry invariably focuses on the cognitive, emotional, and esthetic spheres of a reader. Inner Voice probes the significance of one's life events and stages, exploring deeper, spiritual meaning. The lyrical 'here and now' tends to relate symbolically to both the distant past and the times to come. Through poetic yet lucidly realistic reflection on human condition, Inner Voice sends a message of hope regarding the gradually emerging global society of the non-immediate future. Assisted by his professional background, Poplawski devotes a part of his work to the artistic analysis of personality psychopathologya "the first of its kind in the world's poetry....
Blue Garden
Blue Garden gets its name from the view the astronauts had of planet Earth from dark space. They saw a strikingly lonely, beautiful "blue garden." The book is composed of four interconnected parts. The first, "Garden of Silence," reflects on the specific, subtle shades of everlasting meaning that permeates silence. This part consists of fourteen poems, all relating to one prose piece. The next two parts, "Garden of Light" and "Garden of Shade," strive to explore human virtues and then our vices. Using the method of hyb-writing, each of twenty-four poems is followed by a short, corresponding prose companion. Some of these diverse stories are based on factual events, others are mostly fiction, some even science-fiction. The fourth part, "Mediterranean Gardens," touches on concepts of beauty and joy, hailing the creative powers of the great unknown. Blue Garden is a charitable project in the form of a book. All royalties from this volume go to the Leprosy Mission Canada, helping to cure leprosy in children. Early leprosy is perfectly curable. If fifty-two people buy it, together they give back a normal life to that child. It could be as simple as that...
European Dispute over the Concept of Man
The book represents original research in a field of study rarely pursued while analysing the intellectual dimensions of disputes over ethically sensitive issues that occur in European Union politics. These disputes are generally analysed at ideological, ethical, economic and interstate levels. However, these references do not suffice in understanding the issue, which is related to a divergent perception of the essence of humanity and thus the subject matter of anthropology. The main research objective of the monograph is therefore to reconstruct the sources and the specific European Union way of thinking about the human being. Methodologically, the book expands the understanding of political...
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Status etyki prawniczej
Status etyki prawniczej przedstawia podstawowe zagadnienia etyki prawniczej. Jest próbą odpowiedzi na pytanie, czym jest etyka prawnicza, jakie jest jej miejsce na tle etyki zawodowej oraz jaką rolę etyka zawodowa może odegrać we współczesnym świecie. Książka zawiera rozważania dotyczące m.in. historii etyki prawniczej i zawodów prawniczych oraz kształtowania się ich różnorodnych tradycji. Współcześnie tradycje te podlegają przemianom - jurydyzacji, profesjonalizacji i globalizacji. Książka zawiera także przegląd głównych koncepcji etyki prawniczej oraz propozycję wielopłaszczyznowej teorii etyki prawniczej, która przyjmując perspektywę krytyczną, wyjaś...
