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Ceramide Signaling
The volume assembles current information on the role of ceramide as a signalling molecule in 16 chapters written by leading workers in this area. Specific attention is given to mechanisms of analysis of ceramide and its biophysical properties, on enzymes of ceramide metabolism and down-stream targets of ceramide, on the cross-talk of ceramide signalling with other signalling pathways, and on the role of ceramide in neuronal signalling. Finally, the book closes with a section on the therapeutic implications of ceramide action, in the areas of cannabinoid action, chemotherapy, and atherosclerosis, and illustrates the potential medical significance of delineating the roles of ceramide in cell signalling. This is the first volume specifically devoted to ceramide signalling, and will act as an invaluable resource for basic and medical researchers and graduate students wishing to get a state of the art overview of this rapidly moving field.
Sphingolipid Biology
Sphingolipids are fundamental to the structures of cell membranes, lipoproteins, and the stratum cornea of the skin. Many complex sphingolipids, as well as simpler sphingoid bases and derivatives, are highly bioactive as extra- and intracellular regulators of growth, differentiation, migration, survival, senescence, and numerous cellular responses to stress. This book reviews exciting new developments in sphingolipid biology/sphingolipidology that challenge our understanding of how multicellular organisms grow, develop, function, age, and die.
Cell Lipids
Challenging and provocative overviews are presented in Volume 40 of Current Topics in Membranes. Topics on cell lipids vary from basic themes such as biosynthesis and membrane distribution to the role of lipids in intracellular signaling and membrane flow. This single volume also highlights the roles of lipids in eukaryotic cells and discusses organization of lipids in microdomains.
Bioactive Ceramides in Health and Disease
This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biol...
Comprehensive Natural Products Chemistry
Comprehensive Natural Products Chemistry
Sphingolipids in Disease
Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.
Sphingolipids as Signaling and Regulatory Molecules
This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.
Sphingolipid Metabolism and Cell Signaling, Part B
This volume contains information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. Its companion Volume 311 presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Secretory Systems and Toxins
This volume deals with the relationships between toxins and one of the most fundamental processes in any living cell - the secretory cycle. The reader will find up-to-date information on secretion, generated by experts in this fast evolving field. In the last decade extensive molecular and cellular studies have exposed the molecular similarity among most known secretory systems. In this book secretion is discussed from its basic mode found in yeast up to its most sophisticated version in neurotransmitter release in nerve terminals. A comprehensive view on the mode of action of toxins which block secretion but also those which cause hyper-activation of exocytosis is provided. This book addresses the issue of toxin action by deciphering the molecular and cellular basis of exocytosis in various organisms and cellular contents.
Vesicle Trafficking in Eukaryotes
Current Topics in Membranes, Volume 93 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Receptor-mediated endocytosis in kidney cells during physiological and pathological conditions, Membrane transport and endocytosis in malaria parasites, Impact of Coat Protein on Evolution of Ilarviruses, and Membrane Contact Sites. - Provides the latest information on current topics in membranes - Offers outstanding and original reviews on a range of membrane research topics - Serves as an indispensable reference for researchers and students alike
