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This guidebook on e-science presents real-world examples of practices and applications, demonstrating how a range of computational technologies and tools can be employed to build essential infrastructures supporting next-generation scientific research. Each chapter provides introductory material on core concepts and principles, as well as descriptions and discussions of relevant e-science methodologies, architectures, tools, systems, services and frameworks. Features: includes contributions from an international selection of preeminent e-science experts and practitioners; discusses use of mainstream grid computing and peer-to-peer grid technology for “open” research and resource sharing in scientific research; presents varied methods for data management in data-intensive research; investigates issues of e-infrastructure interoperability, security, trust and privacy for collaborative research; examines workflow technology for the automation of scientific processes; describes applications of e-science.
In the years since the publication of Susumu Ohno's 1970 landmark book Evolution by gene duplication tremendous advances have been made in molecular biology and especially in genomics. Studies of genome structure and function prerequisite to testing hypotheses of genome evolution were all but impossible until recent methodological advances. This book evaluates newly generated empirical evidence as it pertains to theories of genomic evolutionary patterns and processes. Tests of hypotheses using analyses of complete genomes, interpreted in a phylogenetic context, provide evidence regarding the relative importance of gene duplication. The alternative explanation is that the evolution of regulatory elements that control the expression of and interactions among genes has been a more important force in shaping evolutionary innovation. This collection of papers will be of interest to all academic and industry researchers working in the fields of molecular biology, biotechnology, genomics and genome centers.
They reveal how genomic medicine will provide predictive, preventive, and personalized care in the future; discuss "designer babies"; consider the legal status of genetic discrimination as it relates to employment, health insurance, and life insurance; and delve into many other fascinating and timely issues."--BOOK JACKET.
Big Data has been much in the news in recent years, and the advantages conferred by the collection and analysis of large datasets in fields such as marketing, medicine and finance have led to claims that almost any real world problem could be solved if sufficient data were available. This is of course a very simplistic view, and the usefulness of collecting, processing and storing large datasets must always be seen in terms of the communication, processing and storage capabilities of the computing platforms available. This book presents papers from the International Research Workshop, Advanced High Performance Computing Systems, held in Cetraro, Italy, in July 2014. The papers selected for p...
Based on case studies this book offers an insight in various European activities and practices in data management and their interaction with policies and programs. The latter form the background for the following case studies, provide the conceptual framework, at the same time giving an exhaustive understanding of the specific subjects. The case studies share common themes and give a concrete insight into vital issues such as web archiving, digitization of analog archives, researchers’ motivations for sharing data, and how libraries, archives and researchers can collaborate in creating research tools and services.
Workflows may be defined as abstractions used to model the coherent flow of activities in the context of an in silico scientific experiment. They are employed in many domains of science such as bioinformatics, astronomy, and engineering. Such workflows usually present a considerable number of activities and activations (i.e., tasks associated with activities) and may need a long time for execution. Due to the continuous need to store and process data efficiently (making them data-intensive workflows), high-performance computing environments allied to parallelization techniques are used to run these workflows. At the beginning of the 2010s, cloud technologies emerged as a promising environmen...
This unique book addresses the bioinformatic and statistical modelling and also the analysis of microbiome data using cutting-edge QIIME 2 and R software. It covers core analysis topics in both bioinformatics and statistics, which provides a complete workflow for microbiome data analysis: from raw sequencing reads to community analysis and statistical hypothesis testing. It includes real-world data from the authors’ research and from the public domain, and discusses the implementation of QIIME 2 and R for data analysis step-by-step. The data as well as QIIME 2 and R computer programs are publicly available, allowing readers to replicate the model development and data analysis presented in each chapter so that these new methods can be readily applied in their own research. Bioinformatic and Statistical Analysis of Microbiome Data is an ideal book for advanced graduate students and researchers in the clinical, biomedical, agricultural, and environmental fields, as well as those studying bioinformatics, statistics, and big data analysis.
Issues in Genomics and Non-Human Genetic Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Genomics and Non-Human Genetic Research. The editors have built Issues in Genomics and Non-Human Genetic Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genomics and Non-Human Genetic Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Genomics and Non-Human Genetic Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Handbook of Writing for the Mathematical Sciences provides advice on all aspects of scientific writing, with a particular focus on writing mathematics. Its readable style and handy format, coupled with an extensive bibliography and comprehensive index, make it useful for everyone from undergraduates to seasoned professionals. This third edition revises, updates, and expands the best-selling second edition to reflect modern writing and publishing practices and builds on the author's extensive experience in writing and speaking about mathematics. Some of its key features include coverage of fundamentals of writing, including English usage, revising a draft, and writing when your first language...
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.