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Myocardial Ischemia and Preconditioning
Current evidence suggests that the ischemic preconditioning response is a multi-factorial process consisting of an initial early trigger, an intermediate mediator, and an end effector. Each of these steps in is now its own intense area of investigation. The need to render the heart ischemic for a brief period to invoke the preconditioning response is currently the major factor limiting clinical application of this powerful cardioprotective strategy. Recent research efforts have utilized brief exposures to pharmacological agents, in lieu of a brief preconditioning ischemia, to trigger/mimic the ischemic preconditioning-induced response. The World Heart Congress held in Winnipeg in July 2001 provided a forum for the presentation of new insights into the basic mechanisms of ischemia and reperfusion injury, as well as novel strategies to protect the heart from cell death, ventricular arrhythmias, and contractile dysfunction. Many pioneers in the fields of ischemia-reperfusion injury and preconditioning-induced protection presented there and the chapters in this book represent selected papers from these symposia.
Regulation of Coronary Blood Flow
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Coronary Angioplasty: A Controlled Model for Ischemia
Since the introduction of coronary angioplasty in 1977, this procedure has gained a steadily increasing position in the treatment of coronary artery obstmction. From the available evidence it can be estimated, that this thera peutic tool will get even more additional momentum of many ten-thousands of patients to be treated in the next few years, due to a growing fraction of patients who are candidates for this intervention. Information about the indications, benefits and risks of coronary angioplasty is accumulating rapidly in addition to publications about refinements of the technique itself. Recently, a number of investigators have realized that coronary angioplasty is not only a therapeut...
Clinical Applications of Cardiac CT
During the past few years, cardiac CT (CCT) has acquired an increasingly important role as a noninvasive imaging method that allows assessment of coronary heart disease from both the morphological and the functional standpoint. It is quickly becoming a primary clinical tool for the evaluation and follow-up of various conditions related to the heart and great vessels and is providing valuable insights into the natural history of atherosclerosis. The rapid advances in CCT technology, the advent of new clinical applications, and the acquisition of data on prognostic value are just some of the reasons for the publication of this new edition of Clinical Applications of Cardiac CT, little more tha...
Mademoiselle Mori
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Pathology of the Heart and Sudden Death in Forensic Medicine
Addressing the pathology of the heart and cardiovascular system from a forensic perspective, Pathology of the Heart and Sudden Death in Forensic Investigations guides the pathologist toward the effective resolution of cases. It critically reviews pertinent facts by revisiting pathologic findings and comparing them to etiopathogenic hypotheses, prop
Cardiovascular Imaging by Ultrasound
An international meeting of experts on Cardiovascular Imaging by Ultrasound was held in Aachen from 26-27 April, 1991. It provided new and interesting insights into what has already been achieved in ultrasound-based cardiovascular diagnosis and therapy and what will be introduced in clinical practice in the near future. Since the introduction of ultrasound in clinical practice in 1984 there has been no other physical principle that has added and will continue to add so much to clinical diagnosis and therapy. Echocardiography, once established as a non-invasive diagnostic tool, is increasingly becoming an invasive technique for cardiovascular imaging. This book contains the edited contributio...
Ultrasound in Coronary Artery Disease
Today, coronary artery disease is one of the major causes of mortality and morbidity in the Western World. In the last decade many major diagnostic and therapeutic advances have been made, considerably furthering our potential in the management of coronary artery disease. At the same time, a new generation of cardiac tools has appeared. The field which has, perhaps, undergone the most important technological innovations is echocardiography. Nowadays, in fact, the world of ultrasounds ofters the cardiologist a wide range of technical applicatons: two-dimensional real-time imaging, intra-and extra-cardiac Doppler flow measurements, real-time imaging of cardiac struc ture and flow by 2D color D...
Chest Pain with Normal Coronary Angiograms: Pathogenesis, Diagnosis and Management
This book is timely and challenging. Within its pages are commentaries and opinions on the scientific background and explanatory ideas for a complex of symptoms and investigations known as syndrome X. The commonest cause by far of angina pectoris is coronary artery obstruction due to atheromatous lesions both within the wall of the artery and intruding into the lumen; in such patients it is expected that there maybe ST segment depression on atrial pacing or on an exercise test indicating myocardial ischemia. Syndrome X was a term first used in an editorial written by Kemp in 1973. He was referring to patients in group X in a paper from Arbogast and Bourassa. Patients in group X had three fea...
Drug Evaluation in Angina Pectoris
Although there are many books on angina, few are devoted to the important problem of how to evaluate drug efficacy in angina pectoris. Drug Evaluation in Angina Pectoris has two fundamental aims: the first is to review the methodological aspects of drug evaluation in stable and unstable angina pectoris; the second is to provide a logical and methodological background for future studies aimed at assessing the ability of medical treatment to improve prognosis. Part I updates the pathophysiology, clinical presentation and prognosis of angina pectoris. Part II aims to `put in numbers' the symptoms and signs of myocardial ischemia, starting from a revision of the currently used parameters. It is ...
