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Articular Cartilage Tissue Engineering
Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laborat...
Articular Cartilage
Well-known for their inability to heal, articular cartilage injuries often degenerate inexorably to disastrous impairment. Multitudes of treatments have been devised for this problem, but no satisfactory long-term solutions have been established. Written by world-class experts, Articular Cartilage covers the latest research and advancements related to biology, development, pathology, clinical applications, and tissue engineering. This book is useful for rheumatologists, orthopaedic surgeons, cartilage biologists, and cartilage engineers as well as for professionals working in the orthopaedic and other musculoskeletal industries. This book also belongs in the library of primary care physician...
Articular Cartilage Injury of the Knee: Basic Science to Surgical Repair
Articular Cartilage Injury of the Knee is a comprehensive reference that combines the basic scientific knowledge of articular cartilage as it relates to patient health and disease with patient-focused diagnosis and treatment options. This book emphasizes the importance of bridging the divide between basic science and clinical applications in order to select the best possible treatment when injuries occur. Key Features: Provides clinically-relevant information on each topic that can easily be applied in practice Showcases the latest techniques in transplantation and scaffolds for cartilage repair Includes a focused chapter on assessment outcomes after cartilage repair of the knee Written and edited by leading orthopedic surgeons and basic science experts who represent the most current philosophy of effective management of articular cartilage injury of the knee Orthopedic surgeons specializing in the lower extremity will find this book to be an excellent resource that they can consult to guide them in the treatment of patients with articular cartilage injury of the knee.
Articular Cartilage Dynamics
This book explains the anatomy and physiology of cartilage tissue in an integrated way. The emphasis is on how cartilage tissue functions and maintains homeostasis in a challenging mechanical environment. Supported by hundreds of references, the book posts new hypotheses explaining how cartilage adapts and achieves homeostasis in vivo, and tests them against available data. This exploratory approach creates a sense of discovery that the reader can join, or perhaps test themselves through their own research. The main benefit will be obtained by research students and professors looking to understand the deeper concepts that will further their own research, or clinicians (including health professionals and surgeons) who want to gain a deeper physiological understanding of cartilage tissue, which can then serve as a basis for more rational clinical decision-making they need to make on a daily basis. To help bridge the gap between basic science and clinically relevant joint disease, applications and interpretations of key physiological concepts are discussed in the context of osteoarthritis at the end of most chapters.
Articular Cartilage Defects of the Knee
This book reviews current knowledge on the diagnosis and treatment (surgical and non-surgical) of cartilage defects at the knee joint. In the discussion of diagnosis, the focus is primarily on imaging findings, particularly those obtained with MRI. The remainder of the book is devoted to the full range of current conservative and surgical treatments, with attention to both treatment indications and results as reported in the recent literature. In reviewing non-surgical treatment, oral and intra-articular medical management is evaluated and rehabilitation and physical therapy are also considered. The three main types of surgical technique – microfracture surgery and similar procedures, mosaicplasty and related techniques, and autologous chondrocyte transplantation – are then extensively discussed in a series of highly informative chapters. This book will be of great practical value for clinicians, assisting in daily decision making.
Mechanobiology
Over recent years, there has been increasing interest in the fundamental role played by local mechanical parameters in chondrocyte regulation and cartilage dysfunction as a first step in the development of osteoarthritis. This is how the idea of mechanobiology and the concept of mechanotransduction were born in the 90's. Indeed, a broad diversity of physiological phenomena is induced by mechanical stimuli (hearing, orientation to gravity, touch, tissue remodeling...) but the mechanism by which mechanical forces may regulate a physiological response is still unknown. In other respects, the concept of regenerative medicine has recently developed in parallel to this. Regenerative medicine is an...
Diverse Roles of Integrin Receptors in Articular Cartilage
This book examines the expression and function of ß1-integrins in articular chondrocytes. The authors discuss their research and that of others involved in studying chondrocyte ECM adhesion and signal transduction.
Cartilage Injury of the Knee
Cartilage injuries of the knee are common, and diagnosis and treatment options have continued to evolve. This book focuses on current non-operative and surgical treatment strategies for articular cartilage injuries, highlighting the controversies and different approaches from an international perspective. This book includes information on the basic science of cartilage structure and function, expert perspectives on imaging and diagnosing, as well as work-up of athletes and patients presenting with acute or chronic cartilage injury. It also provides an evidence base for current cutting-edge cartilage repair and restoration. Written by leading experts in the field, the book, published in collaboration with ISAKOS and ICRS, is vital reading for orthopaedic and sports medicine surgeons, fellows and residents. It is also of interest to sports trainers, physiotherapists, medical students, postgraduate students, and physical medicine and rehabilitation specialists.
