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Zakim and Boyer's Hepatology
Long considered the defining work in Hepatology, this trusted 2-volume masterwork has been refocused to zero in on just the clinical knowledge you need to provide today's best patient care. The most comprehensive text on the subject, this book is still thoroughly grounded in basic science-but now that science is focused on the most clinically relevant developments. Find definitive coverage of all aspects of liver disease in a new full-color format that keeps pace with your evolving practice. Log on to www.hepatologytext.com to find the entire contents of the 2-volume set online and fully searchable for speedy consultation wherever you go, plus a downloadable image collection for your present...
The Liver
In its Fifth Edition, this classic book retains its traditional strength of relating molecular physiology to understanding disease pathology and treatment as it explores the current state and future direction of hepatology. Painstakingly revised, this edition includes 60 new chapters. As in previous editions, a section called Horizons summarizes advances of extraordinary nature in areas expected to have a substantial impact on hepatology. The Fifth Edition’s Horizons section includes emerging topics such as tissue engineering of the liver, liver-directed gene therapy, decoding the liver cancer genome, and imaging cellular proteins and structure. To preserve essential background information which has not changed while making room for the panoply of major new contributions to understanding of liver disease, 14 chapters from the previous edition are freely available online at gastrohep.com. To view these chapters visit - http://www.gastrohep.com/theliver/
Liver Metabolism and Fatty Liver Disease
About 30% of the general population suffers from Non-Alcoholic Fatty Liver Disease, and the incidence of more serious fatty liver disorders increases with obesity. This discusses the current understanding of development of liver disease and the clinical aspects of fatty liver disease by examining the current knowledge regarding the absorption, metabolism of fat in the liver. It summarizes the current knowledge regarding the involvement of oxidative stress, the metabolic effects inflammation, and the effect of nutrition in the disease development and progression.
Curbside Consultation of the Liver
Are you looking for concise, practical answers to questions that are often left unanswered by traditional liver references? Are you seeking brief, evidence-based advice for complicated cases or complications? Curbside Consultation of the Liver: 49 Clinical Questions provides quick and direct answers to the thorny questions commonly posed during a “curbside consultation” between colleagues. Dr. Mitchell Shiffman has designed this unique reference, which offers expert advice, preferences, and opinions on tough clinical questions commonly associated with the liver. The unique Q&A format provides quick access to current information related to the liver with the simplicity of a conversation b...
Analysis of Chronic Diseases Progression Using Stochastic Modeling
This is a book that handles the non-alcoholic fatty liver disease from the bio-statistical point of view . The statistical method used is Continuous Time Markov Chains ( CTMCs) utilizing the MLE and quasi-Newton method to estimates the transition rate matrix , once obtained , the transition probability matrix can be estimated by exponentiation of this rate matrix. The transition probability matrix can also be obtained by solving forward Kolmogorov differential equations which yields more stable solution than the matrix exponentiation. The rate probability matrix can then be used to estimate the number of patients in each stage of the disease process as well as the life expectancy in each sta...
Drug Hepatotoxicity, An Issue of Clinics in Liver Disease
Dr. Pyrsopolous has created a comprehensive review on the most important and timely topics in drug heptatotoxicity. He has arraanged for there to be a full span of very basic articles that discuss drug metabolism, hepatotoxicity, and drug-induced acute liver failure as well as other important articles devoted to clinical manifestations and treatment of drug induced hepatotoxicity; Pathological manifestations of drug induced hepatotoxicity; Drug induced cholestasis; Lipid lowering agents induced hepatotoxicity; Herbal ,complementary and alternative medicine induced liver injury; Antiretroviral and anti - HCV DAA related hepatotoxicity; Antibiotic related hepatotoxicity; Acetaminophen related hepatoxicity; NSAIDS induced hepatoxocity; Chemotherapy induced hepatotoxicity; Anti epileptic induced hepatotoxicity; and steatohepatitis induced by drugs.
Hepatocellular Carcinoma
• Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. However, the increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. During this exciting time in the field of HCC basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. Suddenly, there are several new choices of therapy to offer patients. Hepatocellular Carcinoma, 3rd edition addresses this fast-changi...
Upper Gastrointestinal Bleeding Management, An Issue of Gastrointestinal Endoscopy Clinics
Upper gastrointestinal bleeding is the leading emergency leading to hospitalization and urgent endoscopy. The field of gastrointestinal bleeding is rapidly evolving. The epidemiology is changing with more complex older patients on anticoagulant and antithrombotic agents presenting with upper gastrointestinal bleeding. The initial management has rapidly evolved with new transfusion thresholds, the use of risk stratification scores and no more nasogastric tubes. There is new data and recommendations on optimal timing of endoscopy. Medical therapies have also evolved with changes in proton pump inhibitor administration and the use of prokinetics to improve endoscopic visualization. Many modifications in endoscopic therapy have recently been advanced including the use of endoscopic ultrasound guided angiotherapy, topical sprays (i.e. Hemospray) and over-the-scope clips. In order to give optimal care to patients, it is critical that practicing gastroenterologists are aware of the many recent advances in management of patients with upper gastrointestinal bleeding.
A Practical Approach to the Spectrum of Alcoholic Liver Disease, An Issue of Clinics in Liver Disease
The Guest Editor has organized this issue to focus on the clinical management of alcoholic liver disease. Authors have written state-of-the-art reviews on the following topics: Prevalence and Natural History of ALD; Alcohol Metabolism; Immunology in ALD; Histological Findings in ALD; Diagnosis and Management of Alcoholic Hepatitis; Management of Alcohol Abuse; Long Term Management of Alcoholic Liver Disease; Infections in ALD; Nutrition in ALD; Alcohol's Effect on Other Chronic Liver Diseases; Liver Cancer and Alcohol; Evaluation and Selection of Candidates for Liver Transplantation; and ALD and Specific Transplant-Related Issues.
Vitamin E in Human Health
Vitamin E is a well described and established fat-soluble essential micronutrient and as such has to be provided to the human body on a regular basis in order to avoid deficiency and maintain a healthy status. This is well established and also reviewed in a number of publications. However, a huge body of evidence has accumulated over the last decade, or so, which provides new insights on the mode of action of vitamin E, and the biological role of the tocopherol isomers, and sheds new light on the role of vitamin E in human health. Both fundamental knowledge gain and new data on the role and challenges of vitamin E as an essential micronutrient, including emerging evidence on clinical benefit...
