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The Organic Chemistry of Drug Design and Drug Action
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
When Mourning Comes
Feelings of loneliness, isolation, and depression sometimes overcome people who have recently been bereaved, filling them with hopelessness and despair, extinguishing their will to go on living. When Mourning Comes is a unique source of comfort and hope. Written by William B. Silverman--a prominent rabbi--and Kenneth M. Cinnamon--a clinical psychologist--When Mourning Comes is not a book about grief, but rather a guide for the grieving. Full of comforting insights and wise suggestions on how to view and cope with the grief of bereavement, this book draws on the author's own experiences and those of people whom they have known and counseled over the years.
Biogeochemical Cycling of Mineral-Forming Elements
Biogeochemical Cycling of Mineral-Forming Elements
The Crime Numbers Game
In the mid-1990s, the NYPD created a performance management strategy known as Compstat. It consisted of computerized data, crime analysis, and advanced crime mapping coupled with middle management accountability and crime strategy meetings with high-ranking decision makers. While initially credited with a dramatic reduction in crime, questions quic
Functional Data Analysis
Included here are expressions in the functional domain of such classics as linear regression, principal components analysis, linear modelling, and canonical correlation analysis, as well as specifically functional techniques such as curve registration and principal differential analysis. Data arising in real applications are used throughout for both motivation and illustration, showing how functional approaches allow us to see new things, especially by exploiting the smoothness of the processes generating the data. The data sets exemplify the wide scope of functional data analysis; they are drawn from growth analysis, meteorology, biomechanics, equine science, economics, and medicine. The book presents novel statistical technology while keeping the mathematical level widely accessible. It is designed to appeal to students, applied data analysts, and to experienced researchers; and as such is of value both within statistics and across a broad spectrum of other fields. Much of the material appears here for the first time.
Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition
The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. - Illustrates the organic mechanism associated with each enzyme-catalyzed reaction - Makes the connection between organic reaction mechanisms and enzyme mechanisms - Compiles the latest information about molecular mechanisms of enzyme reactions - Accompanied by clearly drawn struc...
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The Arithmetic of Elliptic Curves
The theory of elliptic curves is distinguished by its long history and by the diversity of the methods that have been used in its study. This book treats the arithmetic approach in its modern formulation, through the use of basic algebraic number theory and algebraic geometry. Following a brief discussion of the necessary algebro-geometric results, the book proceeds with an exposition of the geometry and the formal group of elliptic curves, elliptic curves over finite fields, the complex numbers, local fields, and global fields. Final chapters deal with integral and rational points, including Siegels theorem and explicit computations for the curve Y = X + DX, while three appendices conclude the whole: Elliptic Curves in Characteristics 2 and 3, Group Cohomology, and an overview of more advanced topics.
