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This book covers fluid dynamics and fluvial processes, including basics applicable to open channel flow followed by turbulence characteristics related to sediment-laden flows. It presents well-balanced exposure of physical concepts, mathematical treatments, validation of the models/theories, and experimentations using modern electronic gadgets within the scope. In addition, it explores fluid motions, sediment-fluid interactions, erosion and scouring, sediment suspension and bed load transportation, image processing for particle dynamics, and various problems of applied fluid mechanics in natural sciences. Features: Gives comprehensive treatment on fluid dynamics and fluvial process from fund...
Written by a leading researcher in immunology, ImmunoPharmaceuticals specifically focuses on immunologically active drugs recently tested for clinical activity or recently approved for medical use. Each chapter focuses on a single drug or class of drugs and discusses data from basic and preclinical research concerning mechanisms of action. Preclinical models are compared with clinical findings to allow the reader to evaluate the predictive value of those models. Featured drugs are being studied for therapy of cancer, arthritic disease, autoimmune disease, immunodeficiency disease, transplantation, and determination of sepsis. Overviews of the retinoids in cancer therapy and preclinical studies on flavonoids are featured.
Advanced Applications in Manufacturing Engineering presents the latest research and development in manufacturing engineering across a range of areas, treating manufacturing engineering on an international and transnational scale. It considers various tools, techniques, strategies and methods in manufacturing engineering applications. With the latest knowledge in technology for engineering design and manufacture, this book provides systematic and comprehensive coverage on a topic that is a key driver in rapid economic development, and that can lead to economic benefits and improvements to quality of life on a large-scale. - Presents the latest research and developments in manufacturing engineering - Covers a comprehensive spread of manufacturing engineering areas for different tasks - Discusses tools, techniques, strategies and methods in manufacturing engineering applications - Considers manufacturing engineering at an international and transnational scale - Enables the reader to learn advanced applications in manufacturing engineering
This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chap...
This book includes general principles of drug targeting, targeting in the cardiovascular system, tumor targeting, brain targeting, miscellaneous targeting and novel approaches for targeting (new horizons). It is designed in a course-like fashion: from more general and simple to more specific and complex material. This framework will help even unfamiliar readers to learn new topics and navigate in the text. Although the book is aimed primarily at industrial and academic pharmacologists and drug discovery researchers, its design will make the book useful for advanced level graduate students. The book focuses on ligand-mediated drug targeting strategies, with additional chapters on general aspects of drug delivery that are of paramount importance in drug targeting (biological barriers, stealth technologies). Included are topics on targeting of genetic materials important in the biomedical context of the ligand-mediated targeting.
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This book presents state-of-the-art coverage of synthesis of advanced functional materials. Unconventional synthetic routes play an important role in the synthesis of advanced materials as many new materials are metastable and cannot be synthesized by conventional methods. This book presents various synthesis methods such as conventional solid-state method, combustion method, a range of soft chemical methods, template synthesis, molecular precursor method, microwave synthesis, sono-chemical method and high-pressure synthesis. It provides a comprehensive overview of synthesis methods and covers a variety of materials, including ceramics, films, glass, carbon-based, and metallic materials. Many techniques for processing and surface functionalization are also discussed. Several engineering aspects of materials synthesis are also included. The contents of this book are useful for researchers and professionals working in the areas of materials and chemistry.
Immune Checkpoint Biology in Health and Disease, Volume 382 provides in-depth reviews on the latest progress concerning research on immune-checkpoint biology and its immunotherapeutic implications, especially in cancer. Topics connected to immune-checkpoint biology covered in this volume include Novel technologies for applying immune checkpoint blockers, Next-generation deconvolution of transcriptomic data to investigate the tumor microenvironment, Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer, Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients, and much more.Other sections cover Recent advanceme...
This book constitutes the refereed post-conference proceedings of the 8th International Workshop on New Frontiers in Mining Complex Patterns, NFMCP 2019, held in conjunction with ECML-PKDD 2019 in Würzburg, Germany, in September 2019. The workshop focused on the latest developments in the analysis of complex and massive data sources, such as blogs, event or log data, medical data, spatio-temporal data, social networks, mobility data, sensor data and streams.
Proceedings of the NATO Advanced Study Institute, Trieste, Italy, July 10-August 1, 1980