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Long Non-coding RNAs as Novel Therapeutic Targets in Juvenile Myelomonocytic Leukemia
Abstract: Juvenile myelomonocytic leukemia (JMML) treatment primarily relies on hematopoietic stem cell transplantation and results in long-term overall survival of 50-60%, demonstrating a need to develop novel treatments. Dysregulation of the non-coding RNA transcriptome has been demonstrated before in this rare and unique disorder of early childhood. In this study, we investigated the therapeutic potential of targeting overexpressed long non-coding RNAs (lncRNAs) in JMML. Total RNA sequencing of bone marrow and peripheral blood mononuclear cell preparations from 19 untreated JMML patients and three healthy children revealed 185 differentially expressed lncRNA genes (131 up- and 54 downregu...
Incommunicado Reader
The Incommunicado Reader brings together papers written for the June 2005 event, and features: Jan Nederveen Pieterse on Digital Capitalism and Development; Roy Pullens on Migration Management (INC commissioned research); Alexandre Freire on Brasil and the FLOSS process; Solomon Benjamin on the E-Politics of Urban Land; and Maja van der Velden on Cognitive Justice.
A Conversation With Barbara
These writings have evolved properly over living many years on the planet and enjoying observations of my fellow man. It's about learning how to flow within the rhythm of all “LIFE FORMS” and laughing about silly things incredulous human beings do. It’s about loving the human race, and living everywhere on the planet at one time; it’s about you! Note: There is no intention on my part to be cogent as these writings have come about from a knowing heart! Upon using the words man and he, I am referring to the Homo Sapien species which include both male/female gender as we know it at the time of these writings.
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Bitter Root Judgment
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