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All the President's Women
Based on groundbreaking original reporting, an extensive new look at Donald Trump's relationships with women, revealing new accusations of sexual misconduct, exploring the roots of his alleged predatory behavior, and illustrating how Trump's presidency has helped catalyze the #MeToo movement and revitalize women's activism.
The Spider
Who was Jeffrey Epstein? A Pulitzer Prize–nominated journalist unearths never-before-reported details in the most comprehensive account yet of the disgraced financier’s life, death, and criminal web, including the role of Ghislaine Maxwell. An ID Book Club Selection • Featured in the Peacock original documentary series Epstein’s Shadow: Ghislaine Maxwell By now, the basic contours of Jeffrey Epstein’s horrendous crimes—his decades-long serial abuse of young women and underage girls—are familiar. But for all that has been written about Epstein since his shocking death in a lower Manhattan jail cell, an astonishing amount remains unknown. A shy Brooklyn kid turned renegade financ...
Bioisosteres in Medicinal Chemistry
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
The Jazz Theory Book
The most highly-acclaimed jazz theory book ever published! Over 500 pages of comprehensive, but easy to understand text covering every aspect of how jazz is constructed---chord construction, II-V-I progressions, scale theory, chord/scale relationships, the blues, reharmonization, and much more. A required text in universities world-wide, translated into five languages, endorsed by Jamey Aebersold, James Moody, Dave Liebman, etc.
Michigan CPA.
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Molecular Reaction Dynamics
Molecular reaction dynamics is the study of chemical and physical transformations of matter at the molecular level. The understanding of how chemical reactions occur and how to control them is fundamental to chemists and interdisciplinary areas such as materials and nanoscience, rational drug design, environmental and astrochemistry. This book provides a thorough foundation to this area. The first half is introductory, detailing experimental techniques for initiating and probing reaction dynamics and the essential insights that have been gained. The second part explores key areas including photoselective chemistry, stereochemistry, chemical reactions in real time and chemical reaction dynamics in solutions and interfaces. Typical of the new challenges are molecular machines, enzyme action and molecular control. With problem sets included, this book is suitable for advanced undergraduate and graduate students, as well as being supplementary to chemical kinetics, physical chemistry, biophysics and materials science courses, and as a primer for practising scientists.
HCV: The Journey from Discovery to a Cure
Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the development of a whole cell system to study the virus spurred the search for novel direct acting antiviral drugs to cure this disease. This global effort culminated in the development of direct acting antiviral drugs that led to cure rates approaching 100% in all patient populations after only 8-12 weeks of therapy. These efforts resulted in one of the greatest achievements in public health and provides the potential for eliminating HCV as a major...
Trump and Me
'Hilariously scathing' Observer New Yorker reporter Mark Singer's blisteringly funny, close-up profile of President-elect Donald Trump - mogul, showman, braggart, unrestrained id and now leader of the free world - is the ultimate portrait of the man who has everything, except an inner life. 'Gets under the skin of Trump ... An amusing but also terrifying portrayal of a narcissist, with only a fleeting grasp of reality' The Times 'One of the best pieces of writing about Trump ... a classic of the genre' Vice 'Offers clearer insight than any of the detailed biographies written over the years ... very funny ... excellent at describing the disturbing strangeness of Trump's existence' Daily Telegraph
