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This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.
This book is a printed edition of the Special Issue "Wetlands for the Treatment of Agricultural Drainage Water" that was published in Water
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Bu eser, daha önce AKILTAŞI SORULARI adı altında yayınlanmıştır. Eserin içeriği, Mustafa KARNAS'ın METAFİZİK konulu eğitimleri sırasında, zihin açıcı, sorgulanması gereken soruları tespite edip,takipçilerine sorması ve bir akıl yürütme ve ipuçları ile cevapları takipçilerine buldurması şeklinde kuvvetli bir çalışma şeklinde gerçekleştirilmiştir. Eşi, benzeri olmayan, bir başka yerde emsali bulunmayan, NEVİ ŞAHSINA MÜNHASIR bir çalışmadır. Gerçekten de bu dünyada FARKINDA olmak ve FARKINDALIK yaratmak için bu kitapların TEDRİSATINDAN geçilmesinde fayda vardır.
MANAGEMENT OF GENETIC SYNDROMES THE MOST RECENT UPDATE TO ONE OF THE MOST ESSENTIAL REFERENCES ON MEDICAL GENETICS Cassidy and Allanson’s Management of Genetic Syndromes, Fourth Edition is the latest version of a classic text in medical genetics. With newly covered disorders and cutting-edge, up-to-date information, this resource remains the most crucial reference on the management of genetic syndromes in the field of medical genetics for students, clinicians, caregivers, and researchers. The fourth edition includes current information on the identification of genetic syndromes (including newly developed diagnostic criteria), the genetic basis (including diagnostic testing), and the routin...
Atomically dispersed metallic materials (ADMMs) are the most advanced materials used in energy conversion and storage devices to improve their performance for portable electronics, electric vehicles, and stationary power stations. Atomically Dispersed Metallic Materials for Electrochemical Energy Technologies aims to facilitate research and development of ADMMs for applications in electrochemical energy devices. It provides a comprehensive description of the science and technology of ADMMs, including material selection, synthesis, characterization, and their applications in fuel cells, batteries, supercapacitors, and H2O/CO2/N2 electrolysis to encourage progress in commercialization of these...
[Learn how to] prevent and reverse manopause, prostate issues, heart disease, and cancer. See how hormone issues at any age may wreck your relationship, make you fat, and accelerate aging and death. Learn how to safely improve your sexual performance, increase your energy, motivation, and sex drive, and strengthen muscles and bones. ... [This book] will show you how to create the kind of lifelong health that will allow you to pursue your passions in life. You will look great, feel great, lose weight, and have better sex! --Page 4 of cover.