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This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.
Corruption and poor governance are acknowledged as major impediments to realizing the right to education and to reaching the Millennium Development Goal of universal primary education by 2015. Corruption not only distorts access to education, but affects the quality of education and the reliability of research findings. From corruption in the procurement of school resources and nepotism in the hiring of teachers, to the buying and selling of academic titles and the skewing of research results, major corruption risks can be identified at every level of the education and research systems. Conversely, education serves as a means to strengthen personal integrity and is a critical tool to address...
This pocket-sized reference on key environmental data for over 200 countries includes key indicators on agriculture, forestry, biodiversity, energy, emission and pollution, and water and sanitation. The volume helps establish a sound base of information to help set priorities and measure progress toward environmental sustainability goals.
The nearly 150-year-old sport of cycling had its first competition in France in 1868. Soon afterward, the need arose for purpose-built cycling tracks because of poor road conditions at the time. Racing on blocked off pieces of street or grass soon evolvedinto racing on special tracks called velodromes. This development marked the split into what are still the two main forms of cycling competition: road racing and track racing. Initially, track cycling was more popular in terms of public attention and money to be earned by racers, but this gradually changed in favor of road racing, which has been the most popular form of cycling since at least the end of World War II. The Historical Dictionar...
First multi-year cumulation covers six years: 1965-70.
This is the fourth Special Issue in Pharmaceuticals within the last six years dealing with aspects of radiopharmaceutical sciences. It demonstrates the significant interest and increasing relevance to ameliorate nuclear medicine imaging with PET or SPECT, and also radiotherapeutical procedures.Numerous targets and mechanisms have been identified and have been under investigation over the previous years, covering many fields of medical and clinical research. This development is well illustrated by the articles in the present issue, including 13 original research papers and one review, covering a broad range of actual research topics in the field of radiopharmaceutical sciences.
The French were the archenemies of the British and her American colonies, particularly after the French and Indian War which was begun by George Washington. So, why did America look to the French as their principal ally in the American Revolution and why did General George Washington choose a Frenchman as his chief engineer? This biography of Louis Duportail, founder and first Commandant of the Army Corps of Engineers, begins by exploring those questions. It then explores the life of this man, who is virtually unknown in America and less known in his native France. This is an unique biography about an overlooked, even obscure, French officer that was instrumental in the American cause for in...