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As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field.
The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a 'quality lead', where these 'quality leads' come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.*Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect
This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas am...
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future. - Contributions from leading authorities and industry experts - Informs and updates on all the latest developments in the field
Only recently was it determined that two of the world's most devastating plagues, the plague of Justinian and the medieval Black Death, were caused by distinct strains of the same pathogen. Use of paleomicrobiological techniques led to this discovery. This work is just one example of the historical mysteries that this emerging field has helped to clarify. Others, such as when tuberculosis began to afflict humans, the role of lice in plague pandemics, and the history of smallpox, are explored and further illuminated in Paleomicrobiology of Humans. Led by editors Michel Drancourt and Didier Raoult, the book's expert contributors address larger issues using paleomicrobiology. These include the ...
As the title indicates, this unique resource is a manual on comparative linguistics, with the examples taken exclusively from Semitic languages. It is an innovative volume that recalls the earlier tradition of textbooks of comparative philology, which, however, exclusively treated Indo-European languages. It is suited for students with at least a year of a Semitic language. By far the largest component of the book are the nine wordlists that provide the data to be manipulated by the student. Says reviewer Peter Daniels, the wordlists "constitute a unique resource for all of comparative linguistics--a considerable quantity of uniform data from a host of related languages. They would be useful for any class in comparative linguistics, not just for those interested specifically in Semitic." Scattered throughout the text are 25 exercises based on the wordlists that provide a good introduction to the methods of comparativists. Also included are paradigms of the phonological systems of ten Semitic languages as well as Coptic and a form of Berber. A bibliography that guides the student into further reading in Semitic linguistics completes the volume.
There is an increasing awareness that materials and chemicals produced from fossil fuels are not sustainable, both in terms of the pollution caused by the extraction and production processes, and the fact that there is only a finite supply of these fossil fuels. Therefore, there is a strong incentive to find sources for chemicals and materials from source materials that we know we can continue to generate. Plants are a source of a wide variety of chemicals, many with interesting properties, and these chemical feedstocks are considered renewable rather than finite. Green Chemistry and Green Materials from Plant Oils and Natural Acids covers the application of these natural materials in producing polymers, lubricants and plasticisers.
Evolutionary medicine has been steadily gaining recognition, not only in modern clinical research and practice, but also in bioarchaeology (the study of archaeological human remains) and especially its sub-discipline, palaeopathology. To date, however, palaeopathology has not been necessarily recognised as particularly useful to the field and most key texts in evolutionary medicine have tended to overlook it. This novel text is the first to highlight the benefits of using palaeopathological research to answer questions about the evolution of disease and its application to current health problems, as well as the benefits of using evolutionary thinking in medicine to help interpret historical ...
""Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, incl"