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Epilepsy and Alzheimer’s disease: shared pathology, clinical presentations, and targets for treatment
Emerging data suggest a link between Alzheimer’s disease (AD) and epilepsy. AD and other dementias pose increased risk for seizures, with seizure incidence in AD up to ten times greater than in age-matched controls. Mouse models of AD also demonstrate seizures and abnormal spikes or sharp wave discharges (“interictal epileptiform discharges” [IEDs]) on electroencephalography (EEG). Seizures and IEDs may underlie fluctuating cognitive abilities in AD, with the impact of antiseizure medication (ASM) requiring further investigation. Many epilepsy patients have memory and other cognitive deficits, due to multiple factors. Most adult-onset epilepsy occurs in people =60 years of age, and epi...
Cognitive Enhancement in CNS Disorders and Beyond
Cognitive Enhancement in CNS Disorders and Beyond compiles a series of educational and thought-provoking chapters from the world's leading cognitive and clinical scientists to describe the latest research on methods for improving cognition in healthy people and those with cognitive disorders.
Wyllie's Treatment of Epilepsy
Wyllie's Treatment of Epilepsy: Principles and Practice, 6th edition provides a broad, detailed, and cohesive overview of seizure disorders and contemporary treatment options. Written by the most influential experts in the field and thoroughly updated to provide the most current content, Wyllie’s Treatment of Epilepsy assists neurologists and epilepsy specialists, neurology residents and fellows, and neuropsychologists in assessing and treating their epileptic patients with the latest treatment options. Dr. Wyllie is once again joined by associate editors Drs. Gidal and Goodkin, as well as newcomers Dr. Joseph Sirven of the Mayo Clinic and Dr. Tobias Loddenkemper, Assistant Professor of Neurology at Harvard Medical School, who specializes in epilepsy research and treatment, particularly for the pediatric population. In-depth review of the subspecialties of epileptology, i.e., neuroimaging, epilepsy surgery, antiepileptic medications A comprehensive single-volume text on epileptology Clinically oriented, evidence-based reference Online bank of over 500 board review-style questions highlight key concepts for board examinations and clinical practice
Neurobehavioral Manifestations of Neurological Diseases: Diagnosis & Treatment, An Issue of Neurologic Clinics
This important subject of Diagnosis of and Treatment for Neurobehavioral manifestations of neurologic disease is directed by three leaders of this field - Dr. Alizeza Minagar, Dr. Glen Finney, and Dr. Kenneth Heilman. Topics include: Neurobehavioral testing for mental status; Behavioral neurology of vascular neurology; Alzheimer's disease; Frontotemporal dementia; Traumatic brain injury; Parkinsonian Syndromes (e.g., Parkinson's disease, Lewy body dementia, progressive supranuclear palsy, corticobasal disease, multisystem atrophy); Behavioral neurology of multiple sclerosis and autoimmune encephalopathies; Infectious Diseases (Neuro-AIDS, Neurosyphilis, HSV); Neurobehavioral aspects of systemic disease; Neurobehavioral aspects of epilepsy; Behavioral neurology aspects of nutritional deficiencies; Neurobehavioral aspects of mitochondrial disease; and Medicinal-induced behavioral disorders.
The Digital Mystique
In The Digital Mystique, Sarah Granger—a nationally recognized expert on online culture and social technology—shows us how digital media is shaping our lives in real time. Whether it's how we raise our children, communicate in love and partnerships, support causes, or establish friendships and trust, Granger pinpoints the best ways to seize digital opportunities to make our lives richer and fuller. While the Internet era is one that is frequently criticized as undermining our health, privacy, concentration, and ability to sustain real-world relationships, Granger takes a more optimistic and empowering view. She shares real-life stories and surprising facts about our lives—both online a...
Inherited Metabolic Epilepsies
"This book fills an important and unique niche in pediatric neurology, and will be a frequently referenced textbook for all clinicians caring for children with epilepsy. It is well-organized and readable, and provides essential and up-to-date clinical data on these individually rare, but collectively more common, disorders." -Elaine Wirrell, MD, Neurology "Specialists in pediatric neurology, epilepsy, and biochemical genetics will find this volume to be indispensable for their daily practice. The organized approach to an incredibly complex set of disorders will also benefit trainees trying to make sense of the complex field and developing their own clinical approach, as knowledge about metab...
Inherited Metabolic Epilepsies
The explosion of information in neurogenetics and metabolism mandates increasing awareness of appropriate diagnostic and therapeutic strategies in the setting of certain epilepsies, especially those of very early onset. There are over 200 inherited disorders that are associated with seizures and prompt identification and intervention is crucial for a positive outcome. This text brings together the leading authorities working in this area to present state-of-the-art clinical reviews covering the science, recognition, and treatment of the inherited metabolic epilepsies and related disorders. The book begins with general principles for diagnosis and targeted intervention including screening protocols, laboratory testing, seizure patterns and EEG findings, imaging, new technologies, and the ketogenic diet. The next two sections are devoted to the cohort of specific small molecule and large molecule disorders that are treatable yet can be so vexing to clinicians and investigators. The book concludes with a clinical algorithm designed to be a resource for the physician in search of direction while considering an inherited metabolic disorder as the explanation for a patient with epilepsy.
Inherited Metabolic Epilepsies
The explosion of information in neurogenetics and metabolism mandates increasing awareness of appropriate diagnostic and therapeutic strategies in the setting of certain epilepsies, especially those of very early onset. There are over 200 inherited disorders that are associated with seizures and prompt identification and intervention is crucial for a positive outcome. This text brings together leading authorities presenting state-of-the-art clinical reviews covering the science, recognition, and treatment of the inherited metabolic epilepsies and related disorders. Inherited Metabolic Epilepsies opens with a section on general principles for diagnosis and targeted intervention including scre...
Wyllie's Treatment of Epilepsy
In one convenient source, this book provides a broad, detailed, and cohesive overview of seizure disorders and contemporary treatment options. For this Fifth Edition, the editors have replaced or significantly revised approximately 30 to 50 percent of the chapters, and have updated all of them. Dr. Wyllie has invited three new editors: Gregory Cascino, MD, FAAN, at Mayo Clinic, adult epileptologist with special expertise in neuroimaging; Barry Gidal, PharmD, at University of Wisconsin, a pharmacologist with phenomenal expertise in antiepileptic medications; and Howard Goodkin, MD, PhD, a pediatric neurologist at the University of Virginia. A fully searchable companion website will include the full text online and supplementary material such as seizure videos, additional EEG tracings, and more color illustrations.
