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Hormones and their Actions, Part 1
The aim of these two volumes is to provide an up-to-date text about the developments in the field during the last 5 - 10 years. Authors with an outstanding record both as active investigators and as critical reviewers have been selected. The result is an integrated collection of contributions forming a fundamental reference work for undergraduate and graduate students, and for those involved in research and teaching in biochemistry and related subjects. Part I contains 15 papers dealing with general aspects of hormones and their actions.
The Molecular Basis of Cancer
This book aims to describe the current state of knowledge and possible future developments in a number of major areas of research into the nature, causes and treatment of cancer. The contributing authors have been encouraged to discuss their subjects at the molecular level. It will become apparent to the reader that considerable developments in the understanding of the fundamental nature of cancer, in molecular terms, are constantly being made. This is particularly the case in the area of oncogene research where differences between tumour and normal cells can now be defined in terms of altered expression of DNA sequences. An understanding of the methods available for detecting cancer, of the...
Amino Acids, Peptides and Proteins
Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The A...
Drug Design
Drug Design, Volume X covers promising and current developments in drug design. The book discusses procedures as applied in the practice of drug design; the structural aspects of the structure-activity relationships of neuroleptics; and promising perspectives in the highly actual field of bioactive peptides. The text also describes the application of the dynamic systems analysis to the antihypertensive drug action; polymeric drug delivery systems; and the design of biocompatible polymers. The structure-activity relationships of insect repellents as a basis for the design of such agents, as well as the approaches to the multivariate data analysis in structure-activity relationships, which is an essential aspect of drug design, are also encompassed. Chemists, pharmacologists, bioengineers, and people involved in drug design and manufacture will find the book invaluable.
Advances in Drug Research
Advances in Drug Research, Volume 21 comprises three chapters that deal with the general subject, specific therapeutic class, and chemical family of diverse drugs. The first chapter of this book discusses the absorption and distribution of drugs in the lymphatic system. A presentation of the anti-infective quinolones is provided in Chapter 2, while the design and therapeutic potential of peptides are elaborated in Chapter 3. Other topics covered include lymphotropic carriers and the lymph uptake mechanism; basis of circulation in lymphatic transport of molecules through various routes of administration; and general aspects and characteristics of quinolone antibacterial agents. The mode of action and mechanisms of resistance of quinolones; potent agonists and antagonists of peptides; and inhibitors of atrial natriuretic factor-degrading enzymes are also deliberated in this text. This publication is valuable to drug researchers and students interested in advances in drugs.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Progress in Medicinal Chemistry
There are five main subject areas in this volume in the series on medicinal chemistry. The first is a review of the understanding of Alzheimer's disease and the development of drugs for its treatment; the second, looking at recent efforts in modifying a naturally occuring anticancer (campothecin) for chemotherapy; the third covers the problem of getting a drug to a specific site within the context of phosphates and phosphonates; a survey of sterilization using aldehydes for the destruction of microbes both inside and outside the human body is reviewed in the fourth; and the last chapter is an account of the progress made in the biologically active enantiomer for complex synthetic asymmetric drug molecules.
Small Peptides
Pharmacochemistry Library, Volume 19: Small Peptides: Chemistry, Biology, and Clinical Studies focuses on the processes, reactions, properties, and characteristics of peptides, including analogues and proteases. The publication first takes a look at angiotensin II and bombesin/gastrin-releasing peptide. Topics include conformationally restricted analogues of bombesin, non-peptide antagonists of angiotensin II, receptor subtypes of angiotensin II, and bombesin/GRP antagonists and cancer. The text then elaborates on bradykinin, cholecystokinin, and enkephalin analogues. The manuscript examines luteinizing hormone releasing hormone and somatostatin. Topics include enzymic degradation of somatostatin and analogues, clinical applications of somatostatin analogues, and pharmacological and clinical studies with LHRH agonists and antagonists. The formulation of peptides and inhibitors of aspartyl proteases are also mentioned. The book is a valuable source of information for chemists, biologists, and readers interested in small peptides.
PEGylated Protein Drugs: Basic Science and Clinical Applications
PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
