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This volume reviews the experimental data on drug-radiation interactions. Special emphasis is placed on clinically-useful antitumor drugs. Particular reference is made to appropriate timing, concentration and sequencing of drug-radiation combinations. It includes discussions on the relative merits of experimental data derived from animal versus human tumors. This book also presents a section on the potential for new model systems or alternative test procedures for evaluating therapeutic benefits and cytotoxicities. Results of randomized clinical studies are reviewed with emphasis on recent studies involving protocols specifically designed to test the benefits from optimal integration of chemotherapy with radiotherapy. This book is intended for laboratory researchers in the field and clinicians interested in using the combined modality approach. It is also a useful resource for radiologists, oncologists, and all those interested in cancer research.
This volume records the proceedings at the Sixth School of Thoracic Medicine held at the Ettore Majorana School of International Scientific Culture in June 1982. Foregathered there were a heterogeneous group comprising clinicians, pharmacologists, pathologists, ultra microscopists, biochemists and immunologists and they presented the eighteen papers seen in the contents list. The discussion which followed each paper was faithfully recorded (and where necessary translated) and may be found after each author's presentation. This free discussion is perhaps the most valuable part of the School of Thoracic Medicine, and most clearly defines the present boundaries of knowledge, and the directions in which enquiry is being pursued. The collaboration of many people made the production of this book possible - for translation and the discussion typescript Miss Guiliana de Ferio; for the final typing and layout Miss Co rinne Wade. The illustrations have been dealt with where necessary by Mr. John Griffiths and the production of the book was done at The Midhurst Medical Research Institute prior to its delivery to Plenum Press.
This book opens a window into the lives of British spinsters in the mid-seventeenth to mid-nineteenth centuries, assessing the opportunities open to them and the restrictions placed upon them within different social classes, occupations, and periods. Hill examines how often spinsters were able to earn enough money to live independently, She looks at the part single women played in religious organisations and the role of friendship and letter-writing in their daily lives. She describes the nature of close relationships between women, some lesbian but many others not. Exploring the spinsters' possibilities of escape from restrictive lives, particularly by emigration or crossdressing, she discusses how successful these were. She provides details about the degree of surveillance single women suffered from the authorities and how often they were seen as a threat to social order. Finally she addresses the question of whether all spinsters of this era were suffering victims or potential viragoes, or neither.
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About half of all species under threat of extinction in the world today are plants. The loss of plant biodiversity is disturbing for many reasons, but especially because it is a reflection of the growing disconnect between humans and nature. Plants have been used for millennia in traditional systems of healing and have held a significant place in drug development for Western medicine as well. Despite the recent dominance of synthetic drug production, natural product discovery remains the backbone of drug development. As the diversity of life on Earth is depleted and increasing numbers of species become lost to extinction, we continue to lose opportunities to achieve advances in medicine. Thr...
How basic chemical ideas help advance the understanding and treatment of disease Biomedical Chemistry presents clear, concise coverage of the application of chemistry to drug discovery and determination of disease etiology, highlighting its role in the explosive growth of biotechnology and molecular biology. Through expert contributions from leading researchers in diverse fields, the book provides readers with an understanding of how fundamental chemical concepts are used in the development of novel approaches to the major problems in medicine today. The authors explain both the science and reasoning underlying each experimental approach, exploring cutting-edge developments in AIDS, cancer, ...
First multi-year cumulation covers six years: 1965-70.