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Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
It's a critical cliché that Cervantes' Don Quixote is the first modern novel, but this distinction raises two fundamental questions. First, how does one define a novel? And second, what is the relationship between this genre and understandings of modernity? In Forms of Modernity, Rachel Schmidt examines how seminal theorists and philosophers have wrestled with the status of Cervantes' masterpiece as an 'exemplary novel', in turn contributing to the emergence of key concepts within genre theory. Schmidt's discussion covers the views of well-known thinkers such as Friedrich Schlegel, José Ortega y Gasset, and Mikhail Bakhtin, but also the pivotal contributions of philosophers such as Hermann Cohen and Miguel de Unamuno. These theorists' examinations of Cervantes's fictional knight errant character point to an ever-shifting boundary between the real and the virtual. Drawing from both intellectual and literary history, Forms of Modernity richly explores the development of the categories and theories that we use today to analyze and understand novels.
Is your firm’s board creating value—or destroying it? Change is coming. Leadership at the top is being redefined as boards take a more active role in decisions that once belonged solely to the CEO. But for all the advantages of increased board engagement, it can create debilitating questions of authority and dangerous meddling in day-to-day operations. Directors need a new road map—for when to lead, when to partner, and when to stay out of the way. Boardroom veterans Ram Charan, Dennis Carey, and Michael Useem advocate this new governance model—a sharp departure from what has been demanded by governance activists, raters, and regulators—and reveal the emerging practices that are de...
What is the appropriate way to taste wine at a restaurant? What type of wine is best served with catfish? 1000 Best Wine Secrets contains all the information novice wine drinkers and experienced connoisseurs alike need to feel comfortable in any restaurant, home or vineyard. 1000 Best Wine Secrets is the book for readers seeking the confidence to select and enjoy the perfect bottle from among the wines of the world. Includes such tips as: Secrets of buying great wine Detecting faulty wine and sending it back Serving wine like a pro Wine tips from around the globe—from Argentina to France and Spain to California Knowing when to drink wine
A Grammar of Modern Indo-European is a complete reference guide to a living Indo-European language. It contains a comprehensive description of Proto-Indo-European grammar, and offers an analysis of the complexities of the prehistoric language and its reconstruction from its descendant languages. Written in a fresh and accessible style, and illustrated with maps, figures and tables, this book focusses on the real patterns of use of Late Indo-European. The book is well organised and is filled with full, clear explanations of areas of confusion and difficulty. It also contains an extensive English - Indo-European, Indo-European - English vocabulary, as well as detailed etymological notes, designed to provide readers with an easy access to the information they require.An essential reference source for the student of Indo-European as a learned and living language, this work will appeal to students of languages, classics, and the ancient world, as well as to general readers interested in the history of language, and in speaking the direct ancestor of the world's largest language family.
This publication examines how opening sequences in films, classic and contemporary, act as hooks to draw the viewer into the film, showing frame by frame how graphics, type and animation are used to create atmosphere, set tone, and lend impact to movies. From Hitchcock and Godard to Tarantino, Luc Besson, and Tim Burton, this large format coffee table book finally illuminates this critical role designers play in filmmaking and gives credit to those that often go uncredited.
The battle for the United Planets hits a fever pitch as the galactic conqueror Mongul beats some of the rulers of the galaxy to death and then heads for Earth! The only thing standing in his way? Superman! Meanwhile, back on Earth, the truth that Clark Kent is Superman continues to spiral out all over the world, and now the Daily Planet’s competition is gunning for his wife, Lois Lane!
Poetry. Women's Studies. Essay. Translation Theory. Translated from the German by Sophie Seita. "This bi-floral or even tri-floral book of poems is for falselandy neighbouring nearspeakers who prefer to hold ear to phoneme to wit. Arranged according to the pleasures of a collaborative conversation between co-translating poets, sinuous between the structured palate and the muscular tongue, Subsisters coheres by means of a joyous principle of augmentation. Wolf and Seita have rendered authority moot; Value here is chosen conviviality. Lightness, charm and play clarify the discovery that all language is polylingual, all worth in shared joy only."--Lisa Robertson
This masterful book from top experts provides clinical insights on reverse shoulder arthroplasty gleaned from hands-on refinement of shoulder replacement techniques. Years of significant biomechanical and clinical research yielded invaluable knowledge that led to important improvements in functional outcome and implant durability. Among these refinements were stronger polyethylene derivatives, better ingrowth technology, and improved connection devices. As the durability and longevity of implant technology increased, younger active patients became suitable candidates for this procedure. In fact, RSA has played a pivotal role in making shoulder arthroplasty the fastest growing implant technol...