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Measurement in Medicine
The success of the Apgar score demonstrates the astounding power of an appropriate clinical instrument. This down-to-earth book provides practical advice, underpinned by theoretical principles, on developing and evaluating measurement instruments in all fields of medicine. It equips you to choose the most appropriate instrument for specific purposes. The book covers measurement theories, methods and criteria for evaluating and selecting instruments. It provides methods to assess measurement properties, such as reliability, validity and responsiveness, and interpret the results. Worked examples and end-of-chapter assignments use real data and well-known instruments to build your skills at implementation and interpretation through hands-on analysis of real-life cases. All data and solutions are available online. This is a perfect course book for students and a perfect companion for professionals/researchers in the medical and health sciences who care about the quality and meaning of the measurements they perform.
Preventing and Treating Missing Data in Longitudinal Clinical Trials
Focuses on the prevention and treatment of missing data in longitudinal clinical trials, looking at key principles and explaining analytic methods.
Applied Mixed Model Analysis
Emphasizing interpretation of results, this hands-on guide explains why, when, and how to use mixed models with your data.
Genomic Clinical Trials and Predictive Medicine
Genomics is majorly impacting therapeutics development in medicine. This book contains up-to-date information on the use of genomics in the design and analysis of therapeutic clinical trials with a focus on novel approaches that provide a reliable basis for identifying which patients are most likely to benefit from each treatment. It is oriented to both clinical investigators and statisticians. For clinical investigators, it includes background information on clinical trial design and statistical analysis. For statisticians and others who want to go deeper, it covers state-of-the-art adaptive designs and the development and validation of probabilistic classifiers. The author describes the development and validation of prognostic and predictive biomarkers and their integration into clinical trials that establish their clinical utility for informing treatment decisions for future patients.
Patient-Centered Measurement
Patients often are asked to fill out questionnaires before or after going to the doctor's office or hospital. What is the point of these questionnaires? Why do the questions often seem irrelevant? Does it matter if patients fill them out or ignore them? This book addresses these questions while also providing historical context about how these questionnaires became so popular. These questionnaires, which philosopher Leah M. McClimans calls 'Patient-Centered Measures' have a fascinating history that combines the contemporary emphasis in medical ethics on patient-centered care with the contemporary preoccupation with evidence-based medicine (the idea that medical decisions should be based on empirical evidence). Patient-centered measures sit between these two concerns and thus serve as an excellent example of a medical technology for the twenty-first century.
Aging in European Societies
Between longer life expectancies and declining birth rates, Europe’s elder population is growing into a sizable minority with considerable impact on nations, health systems, and economies—in other words, global implications as well as local and regional ones. Those investing in the health of older adults need a double perspective: the social and clinical complexity of aging and the larger forces shaping these experiences. Aging in European Societies examines aging trends across the continent, analyzing individual and collective variables that affect the lives of older adults, and drawing salient comparisons with other parts of the world. An interdisciplinary panel of experts provides the...
Patient Reported Outcomes and Quality of Life in Surgery
This book provides a guide to the assessment of quality of life and patient reported outcomes measures in general surgery. The rapidly emerging field helps contextualise patients and helps the decision-making process within health economics, bedside medicine, public health, and health policy. All subspecialties of general surgery are covered, as well as the core principles of quality of life. The book aims to demonstrate how clinicians and policymakers can easily get access to a single source of patient reported outcomes measures and quality of life evidence to help them make the best-informed decisions in the field of general surgery. This book is relevant to healthcare managers, doctors, allied health professionals, healthcare scientists, consultants, healthcare economists, and medical statisticians working in healthcare.
Recent Developments in Graves’ Ophthalmopathy
Recent Developments in Graves' Ophthalmopathy offers an overview of the pathogenesis, assessment and management of patients with thyroid-associated eye disease. Each chapter is written by an expert and truly represents the current state of the art on the particular topic. This book can therefore almost be considered a textbook on this enigmatic disorder. Recent Developments in Graves' Ophthalmopathy is designed for all those interested in this disease, including basic scientists, clinical endocrinologists, ophthalmologists, radiotherapists, and orbital surgeons. The book gives a comprehensive overview of all aspects of Graves' ophthalmopathy. Subjects covered include the pathology of Graves' eye disease and the controversial views on its autoimmune pathogenesis; assessment of the eye changes using reliable measurements; medical management of Graves' eye disease with an overview of the many treatment options available to the clinician, including orbital radiotherapy and other immunosuppressive treatments; management of the thyroid disease; and finally, the techniques for performing various surgical procedures, which are explained and illustrated.
Spin Cycle
This volume was first published by Inter-Disciplinary Press in 2016. Everyday individuals, businesses, government institutions and researchers seek to uncover the true meaning of happiness in order to advance themselves or their causes. The search is ongoing since happiness is both subjective and objective. The same applies to hope. What are the thought processes or foundations that foster hope and thus, move people forward even when the obvious indicators and circumstances suggest otherwise? The numerous activities involved in defining, building and maintaining hope and happiness are never straightforward. Instead imagine that there is a way to spin the two to create such a belief that those who seek hope and happiness perceive success in its acquisition. Even though it is a cycle of highs, lows, ups and downs. This collection of papers will stir readers and evoke thoughts and emotions of hope and happiness based in spirituality, reality and personal perception. Perhaps an assessment of personal hope and happiness will derive from this very special collection of works presented here.
Thyroid Eye Disease
Patients aftlicted with thyroid eye disease or Graves' ophthamopathy (GO) may experience not only pain and visual loss, but also disfigurement. Full understanding of pathogenesis has been elusive, and treatment modalities are imperfect. As with other conditions, more effective intervention will follow only after a better understanding of pathogenesis is reached. The goal of this volume is to give an overview by leaders in the field of the present state of the art both in pathogenesis and clinical aspects of GO. Much attention has been directed towards determining which cells within the orbit are targets of the autoimmune process, and how these and other cells might participate in the local i...
