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Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)
Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer's disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.
A Paris Secret
A sweeping tale of ambition and passion in the shattered world of post-war Paris - perfect for fans of Santa Montefiore and Kate Furnivall 1952. In the fragile atmosphere of post-war Paris, Sophie Bernot is training as a heart surgeon. A young woman in a man's world, Sophie is determined to bury her past and forge her medical career, whatever the costs. Across the channel, Sebastian Ogilvie is burning with ambition for his first architectural project. As his schemes lead him to France, and to a chance encounter with Sophie, his future seems full of promise. But when Sophie and Sebastian find themselves entangled in a brief, passionate affair, they each face a choice that will change their lives irrevocably, and a secret that will take years to be uncovered... Sweeping from Paris to London, to the snow-capped peaks of the Alps, this is an unforgettable story of passion, heartache and forgiveness.
Paisajes neuronales
La muestra presenta imágenes de asombroso aspecto artístico, dibujos realizados por Ramón y Cajal, con el objetivo primordial de atraer al público general al estudio del cerebro y acercarlo a la comprensión científica en el estudio del cerebro, además de trazar una línea educativa y didáctica que abarcaría desde las investigaciones de Ramón y Cajal, padre de la neurociencia moderna, hasta los resultados determinados por los avances científicos y la aplicación de las nuevas técnicas y herramientas.
Traité du cerveau
• Quelles ont été jusqu’à aujourd’hui les grandes conceptions du cerveau et les découvertes clés qui ont permis de mieux le connaître ? Quels sont les défis auxquels la science du cerveau se heurte ? • Comment se forme-t-il ? Quels sont ses composants ? Comment fonctionne-t-il ? • Quels sont les mécanismes de la vision, de l’audition, du goût, de la douleur ? • Comment le cerveau assure-t-il nos mouvements ? • Quels sont les processus qui permettent la mémoire, l’apprentissage, la communication ? Voici tout ce qu’il faut savoir sur le siège de nos sensations, de nos émotions, de nos pensées et de nos actes les plus élémentaires. Un instrument de travail indispensable Michel Imbert, neurophysiologue, spécialiste des sciences cognitives, est professeur émérite à l’université Pierre-et-Marie-Curie, directeur d’études à l’école des hautes études en sciences sociales et membre de l’Institut universitaire de France.
Caroline
"Caroline knows best." Caroline's mother ran away from her father when Caroline was four years old, and her father and stepmother died fifteen years later, leaving her with a young step-brother and two young step-sisters to bring up. Orphaned, and in the care of their eldest sister, the three children grow up in a world where one thing is true: "Caroline knows best." The children adore her, but as they grow up and spread their wings, tension creeps into formerly happy relationships as Caroline cannot bear to relinquish her hold on them. Having sacrificed her own life for the children, to whom she is practically a mother, Caroline values loyalty above all else; but when she invites a guest into her home, she is not prepared for the resulting shift in allegiances in her long-established realm. First published in 1936, Caroline offers a nuanced study of family relationships, of women trapped by duty and respectability, and how good intentions can sometimes have unwanted consequences. One of Richmal Crompton's 'lost' adult novels, Bello is proud to bring eleven of these titles back into print for the first time since original publication.
CAROLINE
The friendship between two men from two very different worlds leads to an unexpected legacy.
Caroline
The year was 1960. The place, Paris. They met by chance on the street in front of the small hotel where they both had taken lodging-the author, an American newspaperman; and a pretty girl with light brown hair cropped short, unruly. Her voice was low pitched, her accent unmistakably English but modulated, restrained, an echo of class, though not of the working class. In profile the sharp line of her jaw tipped upward and her forehead, high and straight, offered a classical image of startling beauty and febrile intensity. Her name was Caroline. For whatever reasons, or for no particular reason at all unless escape from unpleasantness and tedium was a reason, she and the author had drifted into this ancient city. Paris then was magic. Paris was that almost mythical idyll of youth and freedom, and Paris had seduced and bewitched them. Thus begins Alan Littell's memoir of the early years of the girl he one day would marry, from her birth as a British colonial in Cairo in 1939 to their life together in the Europe, England and America of the 1960s.
