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The Hepatitis C Viruses
Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much of the vast literature that has appeared since the identification of the hepatitis C virus RNA genome. It will be an invaluable collection for anyone wanting an up-to-date picture of HCV transmission, molecular virology, immune response, cellular/molecular pathogenesis, and possible avenues for developing effective new therapeutics and vaccines.
Melting Hadrons, Boiling Quarks - From Hagedorn Temperature to Ultra-Relativistic Heavy-Ion Collisions at CERN
This book shows how the study of multi-hadron production phenomena in the years after the founding of CERN culminated in Hagedorn's pioneering idea of limiting temperature, leading on to the discovery of the quark-gluon plasma -- announced, in February 2000 at CERN. Following the foreword by Herwig Schopper -- the Director General (1981-1988) of CERN at the key historical juncture -- the first part is a tribute to Rolf Hagedorn (1919-2003) and includes contributions by contemporary friends and colleagues, and those who were most touched by Hagedorn: Tamás Biró, Igor Dremin, Torleif Ericson, Marek Gaździcki, Mark Gorenstein, Hans Gutbrod, Maurice Jacob, István Montvay, Berndt Müller, Gra...
Milling
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Protein Phosphorylation
Protein phosphorylation is a key mechanism in cellular signaling. This volume presents a state-of-the-art survey of one of the most rapidly developing fields of biochemical research. Written by leading experts, it presents the latest results for some of the most important cellular pathways. Color plates illustrate structural or functional relationships, numerous references provide links to the original literature.
Hot Hadronic Matter
The past decade has seen the development of the operational understanding of fun damental interactions within the standard model. This has detoured our attention from the great enigmas posed by the dynamics and collective behavior of strongly interacting particles. Discovered more than 30 years ago, the thermal nature of the hadronic particle spectra has stimulated considerable theoretical effort, which so far has failed to 'confirm' on the basis of microscopic interactions the origins of this phenomenon. However, a highly successful Statistical Bootstrap Model was developed by Rolf Hagedorn at CERN about 30 years ago, which has led us to consider the 'boiling hadronic matter' as a transient...
Biotherapeutics
Biotherapeutics are often considered to be beyond the reach of the medicinal chemist, but this book demonstrates that chemistry has an essential role in the future success of this area.
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Systems Biology
The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes. Syste...
Progress in Nucleic Acid Research and Molecular Biology
Progress in Nucleic Acid Research and Molecular Biology
Polyamine Drug Discovery
This is the first comprehensive description of the discovery and therapeutic potential of polyamine drugs.
