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Religious Life of Samuel Johns
Samuel Johnson was a deeply religious man and he came to depend on his Christian faith as the principal means by which to endure the pain of existence. He sought throughout his life to render himself worthy of salvation, but the difficulties which he experienced in trying to maintain a high degree of religious discipline - as well as his doubts about God's ultimate concern for man and his fears of his own spiritual unworthiness - led him into periods of madness and a perpetual dread of damnation. Charles Pierce examines the effect of Johnson's religous concerns upon the formation of his complex character, and on the great moral writing that began with The Vanity of Human Wishes and ended wit...
Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing
“The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.”
