You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Contributors to this second volume discuss metal and toxicant toxicity, their environmental sources and methods of action, and their regulation by courts and agencies.
General Description of the Series: Neurotransmitter Transporters focuses on biochemical, electrophysiological, pharmacological, molecular, and cell biological approaches used to study neurotransmitter transport systems. The articles provide detailed descriptions of procedures that should enable the reader to understand how they are accomplished and to repeat or adapt them for their own experimental needs. This book is the first to focus on methods that have been the basis for the rapid development of this area. General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in th...
The Food and Drug Administration (FDA) now requires that all clinical trials for drugs that affect the central nervous system-including psychiatric drugs-are assessed for whether that drug might cause suicidal ideation or behavior. The Institute of Medicine's (IOM) Forum on Neuroscience and Nervous System Disorders hosted a meeting on June 26, 2009, to discuss the FDA's new policy and how to analyze best whether suicidal thoughts predict actual suicidal behavior in the near future.
New and improved therapies to treat and protect against drug dependence and abuse are urgently needed. In the United States alone about 50 million people regularly smoke tobacco and another 5 million are addicted to other drugs. In a given year, millions of these individuals attemptâ€"with or without medical assistanceâ€"to quit using drugs, though relapse remains the norm. Furthermore, each year several million teenagers start smoking and nearly as many take illicit drugs for the first time. Research is advancing on promising new means of treating drug addiction using immunotherapies and sustained-release (depot) medications. The aim of this research is to develop medications that can...
Direct and Allosteric Control of Glutamate Receptors describes in detail recent research that has demonstrated that glutamate receptors are subject to numerous modulatory controls. Significant new insights into the physiology and pathophysiology of the nervous system have been obtained by these discoveries. The sites on the receptor proteins where modulation occurs have provided a platform of opportunities for medicinal chemists to design new therapeutic modalities. These new drugs will be of major significance in treating diseases (such as stroke, Alzheimer's, epilepsy, Parkinson's, Huntington's, neurotrauma, schizophrenia, pain, and anxiety) associated with abnormal excitatory amino acid neurotransmission and function.
Managers trying to do a better job have plenty flavors of the month to choose from: total quality management, continuous improvement, empowerment, teamwork-the list is endless. Everyone is searching for a magic bullet to improve productivity; however, they would have greater success in relying on the core principles of effective management, identified more than fifty years ago. Scholars over the years have presented the principles from different viewpoints and with different terminology, but it boils down to this: Employees want to be masters of their own fate and to have a real sense of ownership. When provided with an organizational climate that allows this, employees are able to use their own intrinsic motivation to improve productivity and maintain high quality and good service. Good managers know that people are the only sustainable competitive advantage. They require practical guidance and tools, not flavors of the month, to support employees in realizing their full potential. Create and sustain a productive workplace from the moment you hire an employee with Core Management Principles.
More people die by suicide each year than by homicide, wars, and terrorist attacks combined. Witnesses and survivors are left perplexed and troubled. Doctors, clinical psychologists, and social workers try to deal with it through their professional routines; sociologists and psychiatrists attempt to provide theoretical explanations of it. In a study of nearly 7000 suicides from 1900 to 1950 in New Zealand and Queensland, Australia, John Weaver documents the challenges that ordinary people experienced during turbulent times and, using witnesses' testimony, death bed statements, and suicide notes, reconstructs individuals' thoughts as they decide whether to endure their suffering. Bridging soc...
Brought together for the first time in a single volume, these eight important and fascinating essays by Nobel Prize-winning psychiatrist Eric Kandel provide a breakthrough perspective on how biology has influenced modern psychiatric thought. Complete with commentaries by experts in the field, Psychiatry, Psychoanalysis, and the New Biology of Mind reflects the author's evolving view of how biology has revolutionized psychiatry and psychology and how potentially could alter modern psychoanalytic thought. The author's unique perspective on both psychoanalysis and biological research has led to breakthroughs in our thinking about neurobiology, psychiatry, and psychoanalysis -- all driven by the...
A must-have far-reaching text that provides readers with a state-of-the-art molecule update on transmembrane transporters, focusing on the methodological approaches currently employed to better understand how transporters work and how they can be used in cutting edge therapies. Each chapter begins with an overview of the importnat biological questions presently being considered in their field, then presents scientific approaches to address these questions. In explaining approaches, the authors cover bench-top protocols, conceptual frameworks, data obtained, and pitfalls common to the techniques.