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From Peptide and Protein Toxins to Ion Channel Structure/Function and Drug Design
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Handbook of Physiology
This volume continues the tradition of thoughtful, in-depth examination of critical subjects in the Handbook of Physiology, though the molecular revolution has transformed cardiovascular research from a stable, mature field into one that is exploding with new findings. The 21 chapters were written by outstanding international investigators in the fields of cell structure, muscle contraction and control, and electrophysiology. They cover basic molecular events but highlight the strong relationships to physiological processes that will soon be important in cardiovascular disease. In the discussions of structure, the emphasis is on normal and abnormal growth as well as the dynamic properties of...
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Fragment-Based Drug Discovery
Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.
