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Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily ...
Conflicts of Colonialism
Using the life of an African clerk who became a king under French colonial rule, this book illuminates conflicts over colonial policies and the application of competing rules of law.
An Extensible Component & Connector Architecture Description Infrastructure for Multi-Platform Modeling
Software engineering for complex systems requires abstraction, multi-domain expertise, separation of concerns, and reuse. Domain experts rarely are software engineers and should formulate solutions using their domain's vocabulary instead of general purpose programming languages (GPLs). Successful integration of domain-specific languages (DSLs) into a software system requires a separation of concerns between domain issues and integration issues while retaining a loose enough coupling to support DSL reuse in different contexts. Component-based software engineering (CBSE) increases reuse and separation of concerns by encapsulating functionalities in components. Components are GPL artifacts, whi...
ZB 2005: Formal Specification and Development in Z and B
This book constitutes the refereed proceedings of the 4th International Conference of Z and B users, ZB 2005, held in Guildford, UK in April 2005. The 25 revised full papers presented together with extended abstracts of 2 invited papers were carefully reviewed and selected for inclusion in the book. The papers document the recent advances for the Z formal specification notation and for the B method, ranging from foundational, theoretical, and methodological issues to advanced applications, tools, and case studies.
Political Writings, 1953-1993
Maurice Blanchot is a towering yet enigmatic figure in 20th-century French thought. Both his fiction and his criticism played a determining role in how postwar French philosophy was written. This volume collects his political writings from 1953 and 1993.
B 2007: Formal Specification and Development in B
This book constitutes the refereed proceedings of the 7th International Conference of B Users, B 2007, held in Besançon, France, January 2007. Coverage in this volume includes industrial applications and case studies using B, integration of model-based specification methods in the software development lifecycle, derivation of hardware-software architecture from model-based specifications, and validating requirements through formal models.
L'orf?vrerie alg?rienne et tunisienne
L'orf?vrerie alg?rienne et tunisienne.
Dictionary of French Family Names in North America
This dictionary contains data not only on the origins of French surnames in Québec and Acadia, a great many of which eventually spread to many parts of North America, but also on those which arrived in the United States directly from various French-speaking European and Caribbean countries. In addition to providing the etymology of the original surnames, it also lists the multifarious variants that have developed over the last four centuries. A unique feature of this work in comparison to other onomastics dictionaries is the inclusion of genealogical information on most of the Francophone migrants to this continent, something which has been rendered possible not only by the excellent record-keeping in French Canada since the very beginnings of the colony, but also through the explosion of such data on the internet in the last couple of decades. In sum, this dictionary serves the dual purpose of providing information on the meanings of French family names on the North American continent, as well as on the migrants who brought them there.
Compensation Schemes for Damages Caused by Healthcare and Alternatives to Court Proceedings
The book discusses compensation mechanisms and other non-judicial means that offer alternatives to court proceedings, designed and provided for within national legal regimes. Such schemes are primarily of a civil or administrative character and are mainly intended to supplement criminal liability for medical negligence. As such, the book focuses on medical malpractice and prospective medical harm from a civil law perspective. It examines the contemporary perspective of a patient-physician relationship, which has evolved from a relation of a quasi-patrimonial character into a partnership of quasi-equal parties, dealing with a medical treatment procedure as a scientific endeavor. It also reviews the extra-legal conditions that are taken into account in compensation arrangements, particularly the need to satisfy a psychological urge for conciliation and empathy on the part of medical personnel. Lastly, the book explores the responsibility of public authorities and healthcare providers to guarantee access to healthcare that is of a sufficient quality, based upon standards provided for in international (and European) law.
