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Molecular Diagnostics
Molecular Diagnostics covers current molecular biological techniques used to identify the underlying molecular defects in inherited disease. Although an increasing number of laboratories, both academic and private are moving in that direction, there are only a few books in the existing literature, and they deal only partly with diagnosis at the molecular level. Each chapter includes the principle and a brief description of the technique, followed by exmples from the authors' own epertise. Contributors are well-known experts in their field, and derive from a variety of disciplines, to ensure breadth and depth of coverage. Examines widely used molecular biology techniques to screen for genetic defects causing inherited disorders Includes state-of-the-art techniques for the detection of the underlying genetic heterogeneity leading to inherited disorders Identification of genetically modified organisms (GMO's) Forensic analysis and every-day issues in a diagnostic laboratory Discusses ethics, genetic counselling and quality management
Quantitative Determination of Decitabine Incorporation Into DNA and Its Effect on Mutation Rates in Human Cancer Cells
Abstract: Decitabine (5-aza-2′-deoxycytidine) is a DNA methyltransferase inhibitor and an archetypal epigenetic drug for the therapy of myeloid leukemias. The mode of action of decitabine strictly depends on the incorporation of the drug into DNA. However, DNA incorporation and ensuing genotoxic effects of decitabine have not yet been investigated in human cancer cell lines or in models related to the approved indication of the drug. Here we describe a robust assay for the quantitative determination of decitabine incorporation rates into DNA from human cancer cells. Using a panel of human myeloid leukemia cell lines we show appreciable amounts of decitabine incorporation that closely corre...
Standardization and Quality Assurance in Fluorescence Measurements II
Analytical chemists and materials scientists will find this a useful addition to their armory. The contributors have sought to highlight the present state of affairs in the validation and quality assurance of fluorescence measurements, as well as the need for future standards. Methods included range from steady-state fluorometry and microfluorometry, microscopy, and micro-array technology, to time-resolved fluorescence and fluorescence depolarization imaging techniques.
Genome Research
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Leipziger Zeitung
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Bioanalytics
Analytical methods are the essential enabling tools of the modern biosciences. This book presents a comprehensive introduction into these analytical methods, including their physical and chemical backgrounds, as well as a discussion of the strengths and weakness of each method. It covers all major techniques for the determination and experimental analysis of biological macromolecules, including proteins, carbohydrates, lipids and nucleic acids. The presentation includes frequent cross-references in order to highlight the many connections between different techniques. The book provides a bird's eye view of the entire subject and enables the reader to select the most appropriate method for any...
Mathematik zwischen Schule und Hochschule
Die Arbeitsgruppe cosh (Cooperation Schule-Hochschule) hat 2013/2014 einen Mindestanforderungskatalog Mathematik der Hochschulen Baden-Württembergs für ein Studium von WiMINT-Fächern vorgelegt. Gemeinsam mit Experten aus allen Schul- und Hochschulbereichen sowie Vertretern der zuständigen Ministerien wurde von cosh eine Tagung zur Glättung des Übergangs von der Schule zur Hochschule im Bereich Mathematik veranstaltet. Sie fand in der Landesakademie für Fortbildung und Personalentwicklung an Schulen und an der Hochschule Esslingen statt. Ergebnisse, Konsequenzen und Empfehlungen – die Podiumsdiskussion zum Thema „Ohne Mathe keine Chance?!“ sind in einem Tagungsband zusammengefasst.
