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This book offers a comprehensive survey of the current state of knowledge in the field of neuro-psychopharmacology in childhood and adolescence. In the first part, the essentials of neuro-psychopharmacology are presented in order to provide a deeper understanding of the principles and particularities in the pharmacotherapy of children and adolescents. This part includes information on neurotransmitters and signal transduction pathways, molecular brain structures as targets for psychiatric drugs, characteristics of psychopharmacological therapy in children and adolescents, ontogenetic influences on pharmacokinetics and pharmacodynamics, and pharmacotherapy in the outpatient setting. The part ...
This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.
The aim of this Research Topic is to discuss the state of the art on the use of Information-based methods in the analysis of neuroimaging data. Information-based methods, typically built as extensions of the Shannon Entropy, are at the basis of model-free approaches which, being based on probability distributions rather than on specific expectations, can account for all possible non-linearities present in the data in a model-independent fashion. Mutual Information-like methods can also be applied on interacting dynamical variables described by time-series, thus addressing the uncertainty reduction (or information) in one variable by conditioning on another set of variables. In the last years...
In this book, Professor Ghahreman Khodadad illuminates the basis of human behavior by examining the structures that underline antisociality. The book’s central thesis is that antisocial people are so thanks to biological and neurological structures. The principle of structure to function is used to argue that the brain, without us being conscious of it, produces our behaviors. If this claim is correct, then antisocial individuals are not accountable for their antisocial behavior, and they should be treated respectfully instead of being punished. Furthermore, prisons should accordingly be converted into rehabilitation, treatment, and behavioral research centers. This is a book for the general reader who is interested in the basis of human behavior. It should also be of interest to psychologists, psychiatrists, neuroscientists, geneticists, neurobiologists, and philosophers.
EEG-based neurofeedback is used as a treatment approach in attention-deficit / hyperactivity disorder (ADHD), a clinically and pathophysiologically heterogeneous child psychiatric disorder. There is increasing evidence for specific effects of neurofeedback when applying 'standard' protocols (slow cortical potentials, theta/beta, sensorimotor rhythm). Knowledge about underlying mechanisms and moderating variables is increasing. Nevertheless, further well-controlled and conducted trials are needed to answer open questions concerning optimisation and individualisation of neurofeedback. Further improvements may develop with new methods and technical developments (e.g., tomographic neurofeedback)...
Worldwide longitudinal studies performed since the 1970s have clearly shown that ADHD persists into adulthood. These findings have stimulated researchers to develop the therapeutic approaches for adult patients, especially in European countries where scientific and clinical interest in ADHD has increased.. In this volume, leading experts from Europe and the United States present their long-term results in order to provide an overview of important aspects of ADHD across the lifespan. These results include epidemiology, neurobiology, psychopathology, longitudinal course, comorbidity and social impairment associated with ADHD. Topics include diagnostic problems and therapeutic options as well as molecular genetic studies. Further, morphological and functional imaging studies in adult ADHD are reviewed, as well as the very important issue of comorbidity. Providing an excellent source of up-to-date information, this publication is essential reading for psychiatrists, neurologists, geneticists, psychotherapists, physicians and other therapists working with ADHD patients.
Why the “nature versus nurture” debate persists despite widespread recognition that human traits arise from the interaction of nature and nurture. If everyone now agrees that human traits arise not from nature or nurture but from the interaction of nature and nurture, why does the “nature versus nurture” debate persist? In Beyond Versus, James Tabery argues that the persistence stems from a century-long struggle to understand the interaction of nature and nurture—a struggle to define what the interaction of nature and nurture is, how it should be investigated, and what counts as evidence for it. Tabery examines past episodes in the nature versus nurture debates, offers a contempora...
A lively, up-to-date overview of the newest research in biosocial criminology What is the relationship between criminality and biology? Nineteenth-century phrenologists insisted that criminality was innate, inherent in the offender’s brain matter. While they were eventually repudiated as pseudo-scientists, today the pendulum has swung back. Both criminologists and biologists have begun to speak of a tantalizing but disturbing possibility: that criminality may be inherited as a set of genetic deficits that place one at risk to commit theft, violence, or acts of sexual deviance. But what do these new theories really assert? Are they as dangerous as their forerunners, which the Nazis and othe...
This textbook provides a state of the art of the knowledge on the prevalence, risk and etiological factors, clinical features, assessment procedures and tools, diagnostic criteria, treatment, and prognosis of the psychiatric disorders encountered in people with intellectual disability (ID) and low-functioning autism spectrum disorder (ASD). ID and ASD represent two meta-syndromic groups of several different conditions, each with particular cognitive and communication features. People with ID/ASD display an increased prevalence of a variety of psychiatric disorders, including psychotic disorders, mood disorders, anxiety and stress-related disorders, somatoform disorders, and obsessive-compuls...