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Purification of Peptides in High-Complexity Arrays
Christopher Schirwitz's thesis focuses on improving the quality of in situ synthesized high-complexity peptide micro arrays. Micro arrays containing proteins or small protein fragments in the form of peptides have become of great interest in proteomic research. With the help of these microarrays a large number of potential target molecules can be screened for interaction with a probe in a short timeframe. However, protein and peptide micro arrays are still lagging behind oligonucleotide arrays in terms of density, quality and manufacturing costs. A new approach developed at the German Cancer Research Center (DKFZ) has improved the synthesis of high-density peptide arrays. The current technol...
Antibody Engineering Volume 1
Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.
Advanced Image Acquisition, Processing Techniques and Applications
"Advanced Image Acquisition, Processing Techniques and Applications" is the first book of a series that provides image processing principles and practical software implementation on a broad range of applications. The book integrates material from leading researchers on Applied Digital Image Acquisition and Processing. An important feature of the book is its emphasis on software tools and scientific computing in order to enhance results and arrive at problem solution.
Laserbasierte Verfahren zur Herstellung hochdichter Peptidarrays
In dieser Arbeit wurden verschiedene Verfahren zur Herstellung von hochdichten Peptidarrays entwickelt. Dabei werden Laser verwendet um spezielle Mikropartikel mit Aminosäuren zu strukturieren. Entweder werden die Partikel erhitzt und angeschmolzen (Combinatorial Laser Fusing) oder durch eine Stoßwelle auf ein anderes Substrat übertragen (Combinatorial Laser Transfer). So entstehen Arrays mit bis zu 1 Mio. Spots pro cm2, während die Anzahl der chemischen Kupplungsschritte minimal bleibt.
Red Storm on the Reich
The Eastern Front witnessed the critical battles between the German and Russian armies which won and lost the Second World War. In Red Storm on the Reich, Christopher Duffy uncovers a military campaign of unprecedented scale and ferocity during which thirty million lives were lost - a deadly harvest in which the slaughter and suffering of German civilians reached unfathomable dimensions. By quoting extensively from the memoirs of Soviet and German commanders and the diaries of infantrymen, Red Storm on the Reich brings to life not only the Russian military assault on the lands of Germany, but also the human drama behind what can only be called epic seiges of the fortress cities of Danzig, Kolberg and Breslau. Christopher Duffy's gripping narrative of this unexplored offensive and the psyches behind it makes for essential reading for all those interested in the Second World War and European history.
New edge of antibiotic development: antimicrobial peptides and corresponding resistance
Antimicrobial peptides, commonly isolated from several organisms, have been considered part of innate immune system and also as potential antimicrobial drugs. Besides its antimicrobial activity, some AMPs also have antifungal activity, inmmunomodulatory and antitumural activities. Lately not only nature has become a source of AMPs. Besides isolation of natural organisms, antimicrobial peptides might be improved or created using computational tools. This opens even more this so amazing field by creating infinite novel and remarkable possibilities. Overall the current issue highlights the relevance of such Research Topic with perspectives to develop entirely new molecules with vast application within health and agricultural field with higher affinity for its target with concomitant reduction of side effects.
International Bibliography of Historical Sciences
Verzeichnis der exzerpierton zeitschriften: 1926, p. [XXXI]-/XVII.
