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Insulin-Like Growth Factors
Over the past five years there has been an explosion of "targeted therapies" for cancer treatment. In most cases, these therapies have been based on pre-clinical data showing that specific molecules play an important role in regulating the malignant phenotype. In breast cancer, there is compelling rationale that such targeted strategies should be successful. Targeting of estrogen receptor ? (ER?) has proven to be a successful way to reduce breast cancer risk, decrease the risk of death and recurrence in an adjuvant setting, and remains the first choice of treatment for advanced disease. With this success, it is hoped that other molecular pathways could also be successfully exploited. This pu...
"A Study Guide for Janet Fitch's ""White Oleander"""
"A Study Guide for Janet Fitch's ""White Oleander"", excerpted from Gale's acclaimed Novels for Students. This concise study guide includes plot summary; character analysis; author biography; study questions; historical context; suggestions for further reading; and much more. For any literature project, trust Novels for Students for all of your research needs."
Twice Upon a Time
A Movie Length Tale from Aisle Seat Books. An unhappy elderly woman on the verge of death is given the opportunity to go back to when she was twenty years old and live her life over again. Is she destined to make the same choices or will she wind up happier than her first time through?
Claptrap
Claptrap is a grand satire of the colonial mentality that governs the theatre festivals of Canada.
Dialogues on Religion—and its Study
Dialogues on Religion—and its Study creatively revives a time-honored genre by offering a series of new speeches on religion (its definition, description, comparison, and explanation) between two old friends who periodically meet throughout the year. Eventually working their way to examining why we tend to call part of our world and our experiences religious, nonspecialist readers can eavesdrop on their conversations, gaining entry to a series of timely, interesting, and sometimes surprisingly complex topics—which all begins with one of them coming across a curious news story on their phone. Treating these dialogues as if they were found objects, the book then also joins in a long tradit...
Current Perspectives on Insulin-like Growth Factor Binding Protein (IGFBP) Research
The family of IGFBPs has been developed by the duplication of genes and genomes and contributes to genetic and functional diversity. Due to the different protein domains present in the molecule, IGFBPs can be seen as mediators of tissue-specific IGF-functions. However, IGFBPs also have IGF-independent functions both inside and outside the cell. These diverse genetic, molecular and functional aspects of IGFBPs are discussed within this Research Topic. Accumulating data provide evidence for the regulation of IGFBP-functions by proteases, which may acutely regulate bioactivity of the IGFs. However, during proteolytic degradation IGFBP-fragments with novel functions can also be formed and are lo...
Transcriptional Regulation in Cancers and Metabolic Diseases
The transcription factor (TF) mediated regulation of gene expression is a process fundamental to all biological and physiological processes. Genetic changes and epigenetic modifications of TFs affect target gene expression during the formation of malignant cells. Extensive work has been done on the critical TFs in various disease models. Despite the success of numerous TF-targeted therapies, there remain significant hurdles understanding the mechanisms, transcriptional targets and networks of physiologic pathways that govern TF action. This effort is now beginning to produce exciting new avenues of research. A clinically relevant topic for genetic change of TF is the mutant isoforms of p53, ...
Hormones and Cancer: Breast and Prostate, An Issue of Endocrinology and Metabolism Clinics of North America
This issue of Endocrinology Clinics brings the reader up to date on the latest information about hormones and cancer of the breast and prostate. The first section focuses on the breast, and topics covered include the following. The role of sex steroids and their receptors in normal breast development; estrogen carcinogenesis in breast cancer; hormonal mechanisms underlying the relationship between obesity and breast cancer; postmenopausal hormone replacement therapy and the risk of breast cancer; aromatase inhibitors, anti-estrogen and SERMS in the treatment of breast cancer; and androgens in breast cancer in men and women. The second section is devoted to the prostate, and topics covered in...
Spruce & Pine Farm
Spruce & Pine Farm: Letters to a Soldier is the third book in the Coming Home for Christmas Series. Any of these books can be read as a standalone. Anderson Rutherford never imagined having an old fashioned penpal when he joined the Marines. Anderson actually has two rays of sunshine that write to him. After five years in service, the unthinkable happens. Anderson is severely wounded and fighting to leave the hospital. Since the day of his tragedy, he can't bring himself to write the ten-year-old, Claire, or the most beautiful soul he's ever imagined, Genesis. The thought of those two seeing him as anything but whole is unbearable. Anderson might be improving physically but every day without...
Direct or Indirect Endocrine and Metabolic Consequences of Malignancies
Malignancies of endocrine organs, such as the pituitary, thyroid, parathyroid, and adrenal glands, significantly affect the metabolism of patients, leading to poor prognosis and high mortality; In addition, malignancies of other organs (such as the pancreas and lung) also cause endocrine or metabolic syndromes, such as Cushing's syndrome, hypoglycemia, hypercalcemia, male mammogenesis, which are called para-neoplastic syndrome. Moreover, the commonly used chemo-, targeted- and immune therapeutic agents (especially immunocheckpoint inhibitors) also have non-negligible impacts on endocrine homeostasis, sometimes life-threatening, through various potential mechanisms. This Research Topic aims to spotlight the direct endocrine consequences of malignancies from endocrine or other organs. Also, it seeks to investigate indirect endocrine consequences of malignancies after therapeutic treatments.
