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G protein-coupled receptors (GPCRs) represent a large and physiologically important class of cell surface receptors. There are approximately 750 known GPCRs present in the human genome that can be subdivided into general classes based upon sequence homology within their transmembrane domains. Therapeutically, GPCRs represent a fertile source for the development of therapies as they are a significant percentage of our current pharmacopeia. Among the three subclasses of GPCRs, the Class A (rhodopsin-like) receptors are by far the most prevalent and extensively studied. However, within the Class A receptors, sub-families of receptors can be distinguished based upon common sequence motifs within...
Lake Ladoga is the largest lake in Europe and, with its surface of 17,891 km2 and volume of 837 km3, it ranks among the top fifteen of the world's freshwater bodies. The ecological condition of Lake Ladoga is of concern to several million people living in its surroundings. There is evidence of water quality degradation and gradual eutrophication of the lake during the past decades; on the other hand, pollution control measures have improved the situation in many of the most polluted sites near industrial effluent sources. The first international Lake Ladoga Symposium was held in St. Petersburg on 22-26 November, 1993. The symposium was attended by 160 scientists, and about half of the papers...
This volume is an exciting collection of short review articles written by leading international experts on the superconducting state in magnetic fields, a rapidly developing area. The philosophy of the book is to emphasize the importance of having experimental and theoretical works side by side. Every effort has been made to match each experimental article with a corresponding theoretical article. The selection of materials includes special topics, new effects and new trends concerning superconductors in low and high magnetic fields. The special topics and new trends include quantum and classical melting of the vortex lattice, new vortex lattice symmetries, vortex core states, nonlinear Meissner effect, symmetry of the order parameter in high-temperature superconductors, and superconductors in high magnetic fields. The book is targeted at a broad audience, including graduate students, postdocs and other researchers active or interested in this field.
Annually published since 1930, the International bibliography of Historical Sciences (IBOHS) is an international bibliography of the most important historical monographs and periodical articles published throughout the world, which deal with history from the earliest to the most recent times. The works are arranged systematically according to period, region or historical discipline, and within this classification alphabetically. The bibliography contains a geographical index and indexes of persons and authors.
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Die Studie "Das Amt und die Vergangenheit" (2010) hat nicht nur in der Öffentlichkeit, sondern auch in der Fachwissenschaft eine lebhafte Debatte über die Rolle des Auswärtigen Amts in der NS-Diktatur hervorgerufen. Der vorliegende Sammelband bezieht sich auf diese Diskussion, die jedoch nicht einfach nur erneut geführt wird. Ziel ist vielmehr eine Bestandsaufnahme der Forschung nach der Debatte. Was wissen wir wirklich über das Auswärtige Amt im Nationalsozialismus, wo liegen die Desiderate, was ist gerade in Arbeit, was unbestritten, was umstritten? Damit gibt der Band eine Antwort auf die Frage, wie sich dieser Streit zwischen Historikern in die Entwicklung der Forschung einordnen lässt und welche Impulse von ihm ausgehen können.
Showcasing moments of convergence between the German and Japanese cultures towards common points of interest over the last one hundred fifty years, the chapters in this book cover such topics as culture, diplomacy, geography, history, law, literature, philosophy, politics, and sports. From the creation of two similar modern nation-states, to the aggressive struggle for national supremacy and subsequent total defeat in 1945, the necessity of coping with their earlier militarism and parallel economic miracles in the postwar era, Germans and Japanese look back on a remarkably similar past.