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Modulation of Cellular Responses in Toxicity
Proceedings of the NATO Advanced Study Institute on the Modulation of Cellular Response in Toxicity, held in Ponte di Legno, Italy , January 24 - February 3, 1994.
Skin Pharmacology and Toxicology
Major skin diseases, including acne, psoriasis and eczcma, affect the majority of the population at some time in their lives. In general, these diseases are physically and psychologically disfiguring for the sufferers; furthermore, by their very chronic nature skin diseases, unlike most other disease processes, present both acute and chronic therapy problems. In addition, the chronic nature of these diseases can present certain economic problems. Firstly, chronic therapy is becoming increasingly expensive and secondly, patients adhering to a strict treatment regimen will frequently be absent from their gainful employment for either medical consultation or treatment. Given that in all NATO co...
Recent Advances in Nervous System Toxicology
This volume addresses some facets of the adverse actions of chemical agents on the central and peripheral nervous systems in developing and mature states. Some of the effects of these chemicals are short-lasting and rapidly reversible; others, especially those that cause structural damage to the nervous system, may result in permanent damage to the organism. The nervous system has several levels of vulnerability to toxic substances. Some substances perturb ion channels or synaptic mechanisms required for the orderly transfer of electrochemical information within the nervous system. Others disrupt sites required for the maintenance of cellular integrity, and these variably result in degenerat...
Toxicology of Pesticides
The protection of human health and food and fiber resources against the ravages of pests of many sorts is a continuous struggle by all people in the world. The use of chemical pesticides as an aid in this struggle is now also global. These chemicals are deliberately added to the environment for the purpose of killing or injuring some form of life. Because pesticides are generally less selectively toxic than would be desired, non-target species, including humans, must be protected from injury by these chemicals. This can only be achieved by thorough understanding of the comparative toxicology of these compounds, and by minimizing human (and other desirable species) exposure. The latter can on...
Molecular Mechanisms of Functional Food
MOLECULAR MECHANISMS OF FUNCTIONAL FOOD Comprehensive resource for understanding state-of-the-art mechanisms behind food health effects This book provides information on the development and validation of functional foods towards their market and industrial application. It covers the available information on developments, efficacy, and testing and safety, while demonstrating the proven or potential effects of food on health and disease. With contributions from the foremost experts in the field, this book will bring readers up to speed on the state of the art in the mechanisms behind food health effects, from their physiological bases to their conception, current uses, and future developments....
Protein Structure and Engineering
Proceedings of the Tenth Course of the International School of Pure and Applied Biostructure (Erice, Italy, June 1989). Knowledge of protein structure and of design and manufacture methods has made it possible to produce proteins of any desired sequence, but progress is limited by inability to predi
DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells
This volume contains edited contributions from the speakers at the NATO Advanced Research Workshop on "DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells" held October 1-6, 1988, at the Abbaye Royale de Fontevraud, Fontevraud France. The meeting was dedicated to Paul Howard-Flanders (Yale University, New Haven, CT. , 1919-1988), whose seminal con tributions to the DNA repair field include the cO-discovery of the excision repair pathway, the elucidation of post-repli cation repair in E. coli, the isolation of the lexA and recC mutants, and his extensive work on the enzymology of RecA. A plethora of recent developments in DNA repair mechan isms and related processes in mammalian cells have advanced our understanding of this field in a number of different areas and have given new emphasis to the ways these systems both resemble DNA repair processes in other groups of organisms in some respects yet are strikingly different from them in others. Within the past decade there have been a number of international conferences on DNA damage and repair mechanisms but none has been focused on these processes in mammalian cells.
Bone Regulatory Factors
Includes all lectures presented at the NATO ASI Course on title] held in Erice, Sicily, May 1989. Covers morphological, chemical, biochemical, physiological and pathophysiological aspects of bone formation and resorption, focusing on regulatory factors and indicating the new directions that are ope
