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Reviews of Physiology, Biochemistry and Pharmacology 156
Gastric acid plays a primary role in digestion as well as in the sterilization of food and water. Gastric juice contains the most concentrated physiological acid solution (pH~1) as a result + – of H and Cl ion secretion [hydrochloric acid (HCl) production] by parietal cells in the oxyntic mucosa of the stomach. The combined output of the parietal cells leads to the sec- tion of 1–2 l of HCl at a concentration of 150–160 mmol/l into the interior of the stomach. In order to facilitate the production of acid, the parietal cell relies on the generation of a high + concentration of H ions that are transported into the lumen of the gland. This process is fa- + + cilitated by activation of th...
The Individual’s Guide to Grants
This book is a work of conscience. It is the product of a long-standing feeling of obligation on my part to write something useful for a special group of people to which you probably belong-individuals who seek grants. In my years as Director of the New York library of The Foundation Center, * each and every day I encountered numbers of individuals look ing for grant money. Although I tried to be as supportive as possible, in the face of the particular problems shared by this group of library users, my own reaction was one of relative helplessness. Simply stated, most of the fund-raising guides, printed directories, and computer files purport edly created to serve the fund-raising public are...
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Chemotherapy
The promise of chemotherapeutic control in the field of oncology seemed, in the beginning, no less bright than it had proven in the field of bacterial disease, and, therefore, its failures were felt all the more. Despite the serendipitous discoveries and inspired insights which tantalized us with striking remissions, or the rare tumors which proved to be fully susceptible to a given agent, in the main, there has been either total failure or a painfully slow acquisition of an armamentarium against a limited number of malignancies. To expect more, however, was the result of ignorance of the malignant cell, for, as has been described in the previous volumes of this series, the exploitable diffe...
Social and Physical Ecologies for Child Resilience: Wisdom from Asia and Africa
Since Emmy Werner and her team discovered on the Hawaiian island of Kauai the “invincible” children who fared well despite exposure to significant household risks, there has been proliferating research on child resilience as a positive response to adverse conditions. The past five decades have seen significant advancements in, and diverse approaches to understanding challenges, facilitative factors, and positive outcomes in the resilience process that involve children. Despite existing and continuously emerging modelings and framings, there appears a common understanding that child resilience unfolds through the interactions between individuals and the environments surrounding them. This Research Topic, therefore, takes an ecological approach to child resilience. While ecologies constitute social spaces that nurture child resilience, they can also refer to the “physical” environments surrounding children. There has been robust empirical evidence suggesting resilience is a shared capacity of the individual and the social ecology (e.g., families, schools, and communities), and more recently of the individual and the physical ecology (e.g., the built or natural environment).
