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Chemistry plays a very important role in the emerging field of synthetic biology. In particular, chemical synthetic biology is concerned with the synthesis of chemical structures, such as proteins, that do not exist in nature. With contributions from leading international experts, Chemical Synthetic Biology shows how chemistry underpins synthetic biology. The book is an essential guide to this fascinating new field, and will find a place on the bookshelves of researchers and students working in synthetic chemistry, synthetic and molecular biology, bioengineering, systems biology, computational genomics, and bioinformatics.
In the last ten years there has been a considerable increase of interest on the notion of the minimal cell. With this term we usually mean a cell-like structure containing the minimal and sufficient number of components to be defined as alive, or at least capable of displaying some of the fundamental functions of a living cell. In fact, when we look at extant living cells we realize that thousands of molecules are organized spatially and functionally in order to realize what we call cellular life. This fact elicits the question whether such huge complexity is a necessary condition for life, or a simpler molecular system can also be defined as alive. Obviously, the concept of minimal cell enc...
Leading researchers draw on the recent literature in Synthetic Biology, from both dedicated journals and broader sources, making this an essential reference to any library supporting this research in this emerging field.
Dedicated to one of the great pioneers of this science, Leslie Orgel, on the occasion of his 80th birthday, this compilation of reviews and original manuscripts provides an overview of the current state of the art, written by some of the major players in this creative domain of 'explorative chemistry' (such as Christian De Duve, Albert Eschenmoser, Gunter Wachtershauser). Since we are still far from finding a definitive answer to the most fundamental of questions in science, 'chemistry' here is defined in its broadest sense. It is against ...
This volume is a collection of lectures given by distinguished physicists from around the world, covering the most recent advances in theoretical physics and the latest results from current experimental facilities. Following one of the principal aims of the School OCo to encourage and promote young physicists to achieve recognition at an international level OCo the students who distinguished themselves for the excellence of their research were given the opportunity to publish their presentations in this volume. Sample Chapter(s). Chapter 1: Experimental Signatures of Strings and Branes (2,702 KB). Contents: Experimental Signatures of Strings and Branes (I Antoniadis); Updates in Local Supers...
Exponentially increasing information on biological organisms coupled with increasing computational power in the past decade have broadened the perspective of fundamental biological research, bringing about considerable promise and unprecedented potential for practical applications in biotechnology. As one emergent discipline, synthetic biology aims to design and engineer novel biologically-based parts, devices, and systems, in addition to redesigning existing, natural biological systems. Although previously relegated to demonstration studies, more recent research in synthetic biology has focused on the rational engineering of industrial microorganisms with the potential to address many of so...
This fully updated and expanded edition addresses the origins of biological and synthetic life from a systems biology perspective.
Gli sviluppi delle scienze moderne, dal Cinquecento ad oggi, sono caratterizzati da rapide fasi di radicali trasformazioni delle teorie e delle visioni del mondo. La rivoluzione astronomica e la rivoluzione evoluzionistica hanno innescato una decentrazione della condizione umana nel cosmo, e hanno allargato gli orizzonti delle nostre conoscenze a ordini di grandezza anche molto lontani da quelli dell’esperienza quotidiana. La rivoluzione astronomica ha aperto le porte alla comprensione dello spazio profondo; la rivoluzione evoluzionistica ha aperto le porte alla comprensione del tempo profondo. Nel libro vengono ripercorse le tappe rilevanti di queste due storie e diventa via via più chia...
The origin of life from inanimate matter has been the focus of much research for decades, both experimentally and philosophically. Luisi takes the reader through the consecutive stages from prebiotic chemistry to synthetic biology, uniquely combining both approaches. This book presents a systematic course discussing the successive stages of self-organisation, emergence, self-replication, autopoiesis, synthetic compartments and construction of cellular models, in order to demonstrate the spontaneous increase in complexity from inanimate matter to the first cellular life forms. A chapter is dedicated to each of these steps, using a number of synthetic and biological examples. With end-of-chapter review questions to aid reader comprehension, this book will appeal to graduate students and academics researching the origin of life and related areas such as evolutionary biology, biochemistry, molecular biology, biophysics and natural sciences.
In this book, the authors present topical research in the study of the ecosystems, economic importance and environmental threats to the Mediterranean Sea. Topics discussed include the need for an economic and business oriented approach to ecosystem services in the Mediterranean Sea; marine pollution from shipwrecks at the bottom of the Mediterranean Sea; the effects of produced formation water (PFW) on the marine environment of the Mediterranean Sea; Secchi depth and water quality control; an environmental modelling plan for the construction and operation of a marine terminal for regasifying liquefied natural gas in the North Adriatic Sea; and a study of bioactive peptides from the venom of the Mediterranean cone snail conus ventricosus.