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The Initiation of Lady de Winter
How did a nice lady like Anne Audley become Lady de Winter, palace spy and arch-villainess of The Three Musketeers? Was she always a dangerous woman? Where did she come from and what is her story? The year is 1623. Europe quakes with dangerous ideas emerging from the halls of science and an unending holy war directed from the citadels of power. Lady Anne avoids political intrigue by living with her husband and toddler in the English countryside. But when a Vatican agent arrives on her doorstep with a scheme involving the king of England, Anne's life is forever transformed. Anne and her husband Harald, Duke of Southampton, are drawn into a Machiavellian plot to negotiate a marriage contract b...
Magnesium in the Central Nervous System
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incomplet...
Pharmacology in Rehabilitation
A volume in the Contemporary Perspectives In Rehabilitation Series, edited by Steven L. Wolf, PhD, PT, FAPTA. Rely on the completely revised and thoroughly updated 4th Edition of this innovative textbook to insure that your students will be able to master this complex content with ease. Organized by body system, each chapter begins with a description of the drug...followed by an explanation of the conditions it treats...and ends with a discussion of how the drug affects physical therapy and how physical therapy may impact drug effectiveness. Dr. Ciccone's easy-to-understand writing style demystifies the science and practice of pharmacology.
Some Antiviral and Antineoplastic Drugs, and Other Pharmaceutical Agents
Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. The evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside ...
Blood Cell Biochemistry
Since the first concepts of gene therapy were formulated, the hemopoietic system has been considered the most natural first target tissue for genetic manipulation. The reasons for this include the fact that a very large number of inherited disorders (including some of the most common disorders, such as the hemoglobinopathies) are disorders of the hemopoietic system, and the large amount of experience in hematopoietic transplantation biology. The consequence of this resulted in the first clinical trial of gene therapy in 1989, where two children suffering from severe combined immune deficiency (ADA-SCID) were transplanted with T-cells express ing adenosine deaminase (the defective enzyme in p...
Medical Management of HIV and AIDS
In the decade since AIDS was first recognised the enormous and worldwide social and medical implications of this disease have been increasingly recognised. The exponential increase in the number of people infected with HIV has been paralleled by the written literature on the subject. When this book was initially conceived the question was why another book? It seemed to me at that time and since, that as HIV presented ever more complex problems, they were best solved when considered within a wider context, using basic principles of individual medical specialties and applying them. For this reason, all the chapter authors were experienced in a particular field and applied that knowledge to HIV...
Chemical-Mechanical Planarization of Semiconductor Materials
This book contains a comprehensive review of CMP (Chemical-Mechanical Planarization) technology, one of the most exciting areas in the field of semiconductor technology. It contains detailed discussions of all aspects of the technology, for both dielectrics and metals. The state of polishing models and their relation to experimental results are covered. Polishing tools and consumables are also covered. The leading edge issues of damascene and new dielectrics as well as slurryless technology are discussed.
Surgery of the Spine and Spinal Cord
This book offers essential guidance on selecting the most appropriate surgical management option for a variety of spinal conditions, including idiopathic problems, and degenerative disease. While the first part of the book discusses the neuroanatomy and biomechanics of the spine, pain mechanisms, and imaging techniques, the second guides the reader through the diagnostic process and treatment selection for disorders of the different regions of the spine, based on the principles of evidence-based medicine. I.e., it clearly explains why a particular technique should be selected for a specific patient on the basis of the available evidence, which is carefully reviewed. The book identifies potential complications and highlights technical pearls, describing newer surgical techniques and illustrating them with the help of images and accompanying videos. Though primarily intended for neurosurgeons, the book will also be of interest to orthopaedic surgeons, specialists in physical medicine, and pain specialists.
