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Synaptic Plasticity
This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses. It explores current concepts on activity-dependent remodeling of the synaptic cytoskeleton and presents the latest ideas on the different forms of plasticity in synapses and dendrites. Synaptic Plasticity in Health and Disease not only supplies readers with extensive knowledge on the latest developments in research, but also with important information on clinical and applied aspects. Changes in spine synapses in different brain disease states, so-called synaptopathies, are explained and described by experts in the field. By outlining basic research findings as well as physiological and pathophysiological impacts on synaptic plasticity, the book represents an essential state-of-the-art work for scientists in the fields of biochemistry, molecular biology and the neurosciences, as well as for doctors in neurology and psychiatry alike.
The Strickland Story
Frederick (Stricklin) Strickland was born ca. 1741 in North Carolina, and died in 1825. He was married to Mary Gibson, who died ca. 1824 in Lawrence Co., Tennessee. They were parents of seven children born ca. 1770 through 1787 in Kentucky and North Carolina. Descendants live in Tennessee, Arkansas, South Carolina, Alabama, Georgia, Oklahoma, Kentucky and elsewhere.
The Autisms
The science of autism has seen tremendous breakthroughs in the past few decades. A multitude of relatively rare mutations have been identified to explain around 15 % of autism cases with many of these genetic causes systematically examined in animal models. This marriage of human genetics and basic neurobiology has led to major advances in our understanding of how these genetic mutations alter brain function and help to better understand the human disease. These scientific approaches are leading to the identification of potential therapeutic targets for autism that can be tested in the very same genetic models and hopefully translated into novel, rational therapies. The Autisms: Molecules to Model Systems provides a roadmap to many of these genetic causes of autism and clarifies what is known at the molecular, cellular, and circuit levels. Focusing on tractable genetic findings in human autism and painstakingly dissecting the underlying neurobiology, the book explains, is the key to understanding the pathophysiology of autism and ultimately to identifying novel treatments.
Design Hydrology and Sedimentology for Small Catchments
The Clean Water Act, with its emphasis on storm water and sediment control in urban areas, has created a compelling need for information in small-catchment hydrology. Design Hydrology and Sedimentology for Small Catchments provides the basic information and techniques required for understanding and implementing design systems to control runoff, erosion, and sedimentation. It will be especially useful to those involved in urban and industrial planning anddevelopment, surface mining activities, storm water management, sediment control, and environmental management. This class-tested text, which presents many solved problems throughout as well as solutions at the end of each chapter, is suitabl...
The Second Age of Computer Science
Between the genesis of computer science in the 1960s and the advent of the World Wide Web around 1990, computer science evolved in significant ways. The author has termed this period the "second age of computer science." This book describes its evolution in the form of several interconnected parallel histories.
NIH Publication
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