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GPCRs: From Deorphanization to Lead Structure Identification
This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry. It is based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006.
Regulation of Chemokine- Receptor Interactions and Functions
This book is a printed edition of the Special Issue "Regulation of Chemokine-Receptor Interactions and Functions" that was published in IJMS
Imaging of the Hand and Wrist
In the past, radiographs of the hand have been described as the “skeleton’s calling card”, showing manifestations of many different diseases. As hand and wrist imaging has become increasingly sophisticated, this observation has become more true than ever. This is a comprehensive, up-to-date textbook on imaging of the hand and wrist. In the first part of the book, the various imaging techniques are discussed in detail. Individual chapters are devoted to radiography, ultrasound, CT, MRI and nuclear medicine. The second part of the book gives an authoritative review of the various pathologies that may be encountered in the hand and wrist, encompassing congenital and developmental abnormalities, trauma, and the full range of localized and systemic disorders. Each chapter is written by an acknowledged expert in the field, and a wealth of illustrative material is included. This book will be of great value to musculoskeletal and general radiologists, orthopaedic surgeons and rheumatologists.
Prokaryotic Systems Biology
This book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new d...
Molecular Targeted Radiosensitizers
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionall...
Advanced Technologies for Protein Complex Production and Characterization
Zusammenfassung: This edited volume discusses the identification, discovery, characterization, structure determination and modeling of multicomponent macromolecular complexes, and as such, it fully complements the first volume (ISBN 978-3-319-27214-6), which targeted methods of recombinant production of protein complexes. This book is divided in 8 sections offering a selection of technologies widely used in the characterization of protein and protein-nucleic acid complexes for different purposes and at different scales. From native electrophoresis methods, that are accessible to any reasonably well-equipped laboratory, to the sophisticated setup required for structure determination by cryo-e...
Index Medicus
None
Looking at Greek Drama
This is a vital and accessible overview of Greek drama from its origins to its later reception, including chapters on authors and dramas in their social and religious context as well as key aspects such as structure, character, staging and music. With contributions by 13 international scholars, world experts in their field, it provides readers with clear, authoritative, up-to-date considerations of both the theory and practice of Greek drama. While each chapter can stand in isolation, the overall structure takes readers on a natural progression – beginning with sources of evidence and origins, considering the major genres and their authors, examining the traditional Aristotelean components...
GPCR Molecular Pharmacology and Drug Targeting
G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.
Advances in Fetal and Neonatal Physiology
To celebrate the Center for Perinatal Biology’s 40th Anniversary, an illustrious group gathered at Loma Linda University in February 2013. That gathering of experts and this volume of the proceedings are a tribute to the founder of the Center, Lawrence D. Longo, M.D. These chapters present contributions from individuals who in some way or another were influenced by Dr. Longo. Covering a wide range of topics, and illustrating the diversity of thinking and scientific interests, these proceedings address basic science through to clinical problems in the developmental programming of health and disease.
