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Parameter Advising for Multiple Sequence Alignment
This book develops a new approach called parameter advising for finding a parameter setting for a sequence aligner that yields a quality alignment of a given set of input sequences. In this framework, a parameter advisor is a procedure that automatically chooses a parameter setting for the input, and has two main ingredients: (a) the set of parameter choices considered by the advisor, and (b) an estimator of alignment accuracy used to rank alignments produced by the aligner. On coupling a parameter advisor with an aligner, once the advisor is trained in a learning phase, the user simply inputs sequences to align, and receives an output alignment from the aligner, where the advisor has automa...
Research in Computational Molecular Biology
This book constitutes the proceedings of the 21th Annual Conference on Research in Computational Molecular Biology, RECOMB 2017, held in Hong Kong, China, in May 2017. The 22 regular papers presented in this volume were carefully reviewed and selected from 184 submissions. 16 short abstracts are included in the back matter of the volume. They report on original research in all areas of computational molecular biology and bioinformatics
Algorithms in Bioinformatics
These proceedings contain papers from the 2009 Workshop on Algorithms in Bioinformatics (WABI), held at the University of Pennsylvania in Philadelphia, Pennsylvania during September 12–13, 2009. WABI 2009 was the ninth annual conference in this series, which focuses on novel algorithms that address imp- tantproblemsingenomics,molecularbiology,andevolution.Theconference- phasizes research that describes computationally e?cient algorithms and data structures that have been implemented and tested in simulations and on real data. WABI is sponsored by the European Association for Theoretical C- puter Science (EATCS) and the International Society for Computational Bi- ogy (ISCB). WABI 2009 was s...
Research in Computational Molecular Biology
This book constitutes the refereed proceedings of the 16th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2012, held in Barcelona, Spain, in April 2012. The 31 revised full papers presented together with 5 keynote lectures were carefully reviewed and selected from 200 submissions. The papers feature current research in all areas of computational molecular biology, including: molecular sequence analysis; recognition of genes and regulatory elements; molecular evolution; protein structure; structural genomics; analysis of gene expression; biological networks; sequencing and genotyping technologies; drug design; probabilistic and combinatorial algorithms; systems biology; computational proteomics; structural and functional genomics; information systems for computational biology and imaging.
Algorithms in Bioinformatics
This book constitutes the refereed proceedings of the 16th International Workshop on Algorithms in Bioinformatics, WABI 2016, held in Aarhus, Denmark. The 25 full papers together with 2 invited talks presented were carefully reviewed and selected from 54 submissions. The selected papers cover a wide range of topics from networks, tophylogenetic studies, sequence and genome analysis, comparative genomics, and mass spectrometry data analysis.
Research in Computational Molecular Biology
This book constitutes the proceedings of the 24th Annual Conference on Research in Computational Molecular Biology, RECOMB 2020, held in Padua, Italy, in May 2020. The 13 regular and 24 short papers presented were carefully reviewed and selected from 206 submissions. The papers report on original research in all areas of computational molecular biology and bioinformatics.
Beyond Donkeys and Elephants
Confronted with two historically unpopular presidential candidates, the American electorate in 2016 delivered a shock to the political system. Less noted, amid the drama of Donald Trump’s victory, was the substantial share of the vote won by minor parties and independent candidates—one of whom, Libertarian Gary Johnson, put in the best third-party performance since Ross Perot’s 1996 Reform Party bid. Even more surprising, at the state-level minor-party candidates made greater inroads, in some states combining to win over 10 percent of the vote. At a time of increasing dissatisfaction with a two-party system, this book provides a much-needed look at the current political party alternati...
Dumb and Dumber
In America’s early days, most immigrants entered America through New York. For many, New York was synonymous with America and the American dream itself—a beacon of hope for the rest of the world. Now, for the first time ever, people are fleeing New York by the millions. Plagued by high taxes, big government, excessive regulations, and other obstacles to liberty, there are few reasons for one to want to remain in the state under Governor Andrew Cuomo’s leadership. And in New York City, which houses nearly half of the state’s population, Mayor Bill de Blasio has been doing everything in his power to accelerate the decline and bring the city back to its pre–Rudy-Giuliani days.
