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Restriction Endonucleases
Restriction enzymes are highly specific nucleases which occur ubiquitously among prokaryotic organisms, where they serve to protect bacterial cells against foreign DNA. Many different types of restriction enzymes are known, among them multi-subunit enzymes which depend on ATP or GTP hydrolysis for target site location. The best known representatives, the orthodox type II restriction endonucleases, are homodimers which recognize palindromic sequences, 4 to 8 base pairs in length, and cleave the DNA within or immediately adjacent to the recognition site. In addition to their important biological role (up to 10 % of the genomes of prokaryotic organisms code for restriction/modification systems!), they are among the most important enzymes used for the analysis and recombination of DNA. In addition, they are model systems for the study of protein-nucleic acids interactions and, because of their ubiquitous occurence, also for the understanding of the mechanisms of evolution.
Stark Arthology
Profiles of sixty-nine artists from northeastern Ohio containing a short biographical sketch, artist's statement, portrait, and photo of a piece of their work. Media they work in include oil, acrylic, watercolor, ceramics, woodworking, sculpture, photography, digital design, pen and ink, fiber arts, stained glass, jewelry making, and mixed media.
Fairy Tales and Fables
An illustrated anthology of well-known fairy tales and Aesop's fables.
The Art Forger's Handbook
The English artist Eric Hebborn (1934-1996) explains the secrets of his forging techniqes in this illustrated work compiled shortly before his death. Drawings previously attributed to artists such as Picasso and Corot were in fact the work of Hebborn and this work provides an insight through explanations of his work. Inks, papers, pigments, monograms and signatures are all explained as well as Hebborn's own often outrageous speculations about the nature of art and value.
Molecular and Cellular Biophysics
Molecular and Cellular Biophysics provides advanced undergraduate and graduate students with a foundation in the basic concepts of biophysics. Students who have taken physical chemistry and calculus courses will find this book an accessible and valuable aid in learning how these concepts can be used in biological research. The text provides a rigorous treatment of the fundamental theories in biophysics and illustrates their application with examples. Conformational transitions of proteins are studied first using thermodynamics, and subsequently with kinetics. Allosteric theory is developed as the synthesis of conformational transitions and association reactions. Basic ideas of thermodynamics and kinetics are applied to topics such as protein folding, enzyme catalysis and ion channel permeation. These concepts are then used as the building blocks in a treatment of membrane excitability. Through these examples, students will gain an understanding of the general importance and broad applicability of biophysical principles to biological problems.
Robert Lachmann's Letters to Henry George Farmer (from 1923 to 1938)
"Robert Lachmann's letters to Henry George Farmer, from the years 1923-38, provide insightful glimpses into his life and his progressive research projects. From an historical perspective, they offer critical data concerning the development of comparative musicology as it evolved in Germany during the early decades of the twentieth century. The fact that Lachmann sought contact with Farmer can be explained from their mutual, yet diverse interests in Arab music, particularly as they were then considered to be the foremost European scholars in the field. During the 1932 Cairo International Congress on Arab Music, they were selected as presidents of their respective committees"--
The Forger's Apprentice
In the late 1960s Elmyr (pronounced el-MEER) de Hory was the world's most talented-and most successful art forger-ever. For over 20 years his bogus masterpieces filtered into prestigious collections on five continents. In 1967 his chicanery ended in a scandal that rocked the art world, although this monocle-wearing charmer's artful deception did not end there. He seduced most everyone he met, counting Marilyn Monroe, Liz Taylor, Montgomery Clift, Rita Hayworth, and Orson Welles among his friends. As a young American Midwesterner, I fell under his spell when I met Elmyr in 1969 on the Mediterranean island of Ibiza, becoming his personal assistant while he became my mentor and closest friend. ...
Industrial Pharmaceutical Biotechnology
This volume focuses on pharmaceutical biotechnology as a key area of life sciences. The complete range of concepts, processes and technologies of biotechnology is applied in modern industrial pharmaceutical research, development and production. The results of genome sequencing and studies of biological-genetic function are combined with chemical, micro-electronic and microsystem technology to produce medical devices and diagnostic biochips. A multitude of biologically active molecules is expanded by additional novel structures created with newly arranged gene clusters and bio-catalytic chemical processes. New organisational structures in the co-operation of institutes, companies and networks enable faster knowledge and product development and immediate application of the results of research and process development. This book is the ideal source of information for scientists and engineers in research and development, for decision-makers in biotech, pharma and chemical corporations, as well as for research institutes, but also for founders of biotech companies and people working for venture capital corporations.
