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Quantitative Models in Life Science Business
This open access book explores the field of life science business from a multidisciplinary perspective. Applying statistical, mathematical, game-theoretic, and data science tools to pharmaceutical and biotechnology business endeavors, the book describes value creation, value maintenance, and value realization in the life sciences as a sequence of processes using the quantitative language of applied mathematics. Written by experts from a variety of fields, the contributions illustrate the shift from a deterministic to a stochastic view of the processes involved, offering a new perspective on life sciences economics. The book covers topics such as valuing and managing intellectual property in life science, licensing in the pharmaceutical business, outsourcing pharmaceutical R&D, and stochastic modelling of a pharmaceutical supply chain. The book will appeal to scholars of economics and the life sciences, as well as to professionals in chemical and pharmaceutical industries.
Accounting for Constraints in Delay Systems
Time-delays are fundamental to understand phenomena in control applications as networked systems, traffic management, control of vibrations, and supply chains. The need for a performance and reliability on these systems has to overcome challenges related to the constraints in the controlled systems. These constraints can be physical, such as input magnitude saturation on actuators, or technological, such as the limited bandwidth in a networked system or the fixed structure in a control architecture, where only a few parameters can be set. This volume provides a wide-ranging collection of methods for the analysis and design of control laws for delay systems with constraints. These methods cover fundamental analytical aspects as, for instance, the stability analysis of Positive Delay systems or the achievable performance of PID controls for delay systems. The book gives valuable material for researchers and graduate students in Automatic Control.
Current Trends in Dynamical Systems in Biology and Natural Sciences
This book disseminates the latest results and envisages new challenges in the application of mathematics to various practical situations in biology, epidemiology, and ecology. It comprises a collection of the main results presented at the Ninth Edition of the International Workshop “Dynamical Systems Applied to Biology and Natural Sciences – DSABNS”, held from 7 to 9 February 2018 at the Department of Mathematics, University of Turin, Italy. While the principal focus is ecology and epidemiology, the coverage extends even to waste recycling and a genetic application. The topics covered in the 12 peer-reviewed contributions involve such diverse mathematical tools as ordinary and partial differential equations, delay equations, stochastic equations, control, and sensitivity analysis. The book is intended to help both in disseminating the latest results and in envisaging new challenges in the application of mathematics to various practical situations in biology, epidemiology, and ecology.
Mastering Frequency Domain Techniques for the Stability Analysis of LTI Time Delay Systems
In many dynamical systems, time delays arise because of the time it takes to measure system states, perceive and evaluate events, formulate decisions, and act on those decisions. The presence of delays may lead to undesirable outcomes; without an engineered design, the dynamics may underperform, oscillate, and even become unstable. How to study the stability of dynamical systems influenced by time delays is a fundamental question. Related issues include how much time delay the system can withstand without becoming unstable and how to change system parameters to render improved dynamic characteristics, utilize or tune the delay itself to improve dynamical behavior, and assess the stability an...
The Basic Approach to Age-Structured Population Dynamics
This book provides an introduction to age-structured population modeling which emphasizes the connection between mathematical theory and underlying biological assumptions. Through the rigorous development of the linear theory and the nonlinear theory alongside numerics, the authors explore classical equations that describe the dynamics of certain ecological systems. Modeling aspects are discussed to show how relevant problems in the fields of demography, ecology and epidemiology can be formulated and treated within the theory. In particular, the book presents extensions of age-structured modeling to the spread of diseases and epidemics while also addressing the issue of regularity of solutions, the asymptotic behavior of solutions, and numerical approximation. With sections on transmission models, non-autonomous models and global dynamics, this book fills a gap in the literature on theoretical population dynamics. The Basic Approach to Age-Structured Population Dynamics will appeal to graduate students and researchers in mathematical biology, epidemiology and demography who are interested in the systematic presentation of relevant models and mathematical methods.
Topics in Time Delay Systems
Time delays are present in many physical processes due to the period of time it takes for the events to occur. Delays are particularly more pronounced in networks of interconnected systems, such as supply chains and systems controlled over c- munication networks. In these control problems, taking the delays into account is particularly important for performance evaluation and control system’s design. It has been shown, indeed, that delays in a controlled system (for instance, a c- munication delay for data acquisition) may have an “ambiguous” nature: they may stabilize the system, or, in the contrary,they may lead to deteriorationof the clos- loop performance or even instability, depen...
Delay Robustness in Cooperative Control
The robustness of various cooperative control schemes on large scale networked systems with respect to heterogeneous communication and coupling delays is investigated. The presented results provide delay-dependent and delay-independent conditions that guarantee consensus, rendezvous, flocking, and synchronization in different classes of multi-agent systems (MAS). All conditions are scalable to arbitrarily large multi-agent systems with non-identical agent dynamics. In particular, conditions for linear agents, for nonlinear agents with relative degree one, and for a class of nonlinear agents with relative degree two are presented. The interconnection topology between the agents is in most cas...
Stability, Control, and Computation for Time-Delay Systems
Time delays are important components of many systems in, for instance, engineering, physics, economics, and the life sciences, because the transfer of material, energy, and information is usually not instantaneous. Time delays may appear as computation and communication lags, they model transport phenomena and heredity, and they arise as feedback delays in control loops. This monograph addresses the problem of stability analysis, stabilization, and robust fixed-order control of dynamical systems subject to delays, including both retarded- and neutral-type systems. Within the eigenvalue-based framework, an overall solution is given to the stability analysis, stabilization, and robust control ...
Time Delay Systems: Methods, Applications and New Trends
This volume is concerned with the control and dynamics of time delay systems; a research field with at least six-decade long history that has been very active especially in the past two decades. In parallel to the new challenges emerging from engineering, physics, mathematics, and economics, the volume covers several new directions including topology induced stability, large-scale interconnected systems, roles of networks in stability, and new trends in predictor-based control and consensus dynamics. The associated applications/problems are described by highly complex models, and require solving inverse problems as well as the development of new theories, mathematical tools, numerically-tractable algorithms for real-time control. The volume, which is targeted to present these developments in this rapidly evolving field, captures a careful selection of the most recent papers contributed by experts and collected under five parts: (i) Methodology: From Retarded to Neutral Continuous Delay Models, (ii) Systems, Signals and Applications, (iii): Numerical Methods, (iv) Predictor-based Control and Compensation, and (v) Networked Control Systems and Multi-agent Systems.
Delay Systems
This volume is the first of the new series Advances in Dynamics and Delays. It offers the latest advances in the research of analyzing and controlling dynamical systems with delays, which arise in many real-world problems. The contributions in this series are a collection across various disciplines, encompassing engineering, physics, biology, and economics, and some are extensions of those presented at the IFAC (International Federation of Automatic Control) conferences since 2011. The series is categorized in five parts covering the main themes of the contributions: · Stability Analysis and Control Design · Networks and Graphs · Time Delay and Sampled-Data Systems · Computational and Software Tools · Applications This volume will become a good reference point for researchers and PhD students in the field of delay systems, and for those willing to learn more about the field, and it will also be a resource for control engineers, who will find innovative control methodologies for relevant applications, from both theory and numerical analysis perspectives.
