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Non-dopamine Lesions in Parkinson's Disease
Parkinson's disease becomes apparent only after substantial loss (>60%) of the dopamine neurons in the substantia nigra. By this time there has already been widespread neural inclusion formation in the peripheral and central nervous system of patients with the disease, although this has only been recognized more recently. Degeneration in these widespread regions of the peripheral and central nervous system is now known to impact on disease symptoms, progression and treatment over time. This book aims to provide a comprehensive review of these non-dopamine lesions in Parkinson's disease by assessing our current knowledge of their presence and pathophysiology, how they relate to different symp...
Non-dopamine Lesions in Parkinson's Disease
In recent years it has become increasingly obvious that PD is more than a disorder of movement with pathology localized to the dopaminergic nigrostriatal pathway. This book therefore seeks to take this discussion into this new area of research and define the nature of the non-dopaminergic features of PD in a new and exciting way. This includes joint discussions by clinicians and pathologists in many chapters to highlight how one disciple can inform the other and by so doing the chapters have an integrated and complete analysis of the topic under discussion.
Textbook of Diabetes
Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-...
Stress and Cardiovascular Disease
The main aim of this book is to evaluate the concept of stress and provide tools for physicians to identify patients who might benefit from stress management. This will incorporate a detailed description of the physiological and pathophysiological consequences of acute and chronic stress that might lead to cardiovascular disease. The book will aim to critically evaluate interventional research (behavioural and other therapies) and provide evidence based recommendations on how to manage stress in the cardiovascular patient. Our intentions are to define and highlight stress as an etiological factor for cardiovascular disease, and to describe an evidence based "tool box" that physicians may use to identify and manage patients in whom stress may be an important contributing factor for their disease and their risk of suffering cardiovascular complications.
Textbook of Paediatric Emergency Medicine E-Book
A comprehensive textbook of paediatric emergency medicine for trainee doctors - covers all the problems likely to present to a trainee in the emergency department. Short concise chapters, with key point boxes at the beginning - easy to use for the hard-pressed trainee. Aims to give a consensus approach to assessment and treatment, based on the latest evidence. Highlights areas of controversy.
Calcium in Internal Medicine
Calcium plays an enormous and varied role in living systems now widely appreciated by clinicians. Calcium in Internal Medicine demonstrates the physiological significance of calcium in clinical medicine and discusses the abnormal calcium metabolism in disorders such as renal failure, hypertension, atherosclerosis and osteoporosis. Hirotoshi Morii (Editor) linked the clinical use of vitamin D analogues in bone diseases, Yoshiki Nishizawa (Editor) researched the connection between calcium metabolism and atherosclerosis and Shaul G. Massry (Editor) was the first to systematize the importance of excess PTH in chronic renal failure. In addition to these areas, Calcium in Internal Medicine covers basic physiology, pathophysiology, nutritional requirements and the role of calcium in the development and treatment of other various diseases. The importance of calcium and its regulatory systems is brought together in one publication providing a useful reference tool for internists, rheumatologists and endocrinologists.
Core Topics in Mechanical Ventilation
Unique text laying out the principles and practicalities of mechanical ventilation aimed at any practitioner.
