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Parkinson's disease becomes apparent only after substantial loss (>60%) of the dopamine neurons in the substantia nigra. By this time there has already been widespread neural inclusion formation in the peripheral and central nervous system of patients with the disease, although this has only been recognized more recently. Degeneration in these widespread regions of the peripheral and central nervous system is now known to impact on disease symptoms, progression and treatment over time. This book aims to provide a comprehensive review of these non-dopamine lesions in Parkinson's disease by assessing our current knowledge of their presence and pathophysiology, how they relate to different symp...
Greenfield's Neuropathology, the world’s leading neuropathology reference, provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The book’s detailed advice on pathological assessment and interpretation is based on clear descriptions of molecular and cellular processes and reactions that are relevant to the development of the nervous system, as well as its normal and abnormal functioning. The information is presented in an accessible way to readers working within a range of disciplines in the clinical neurosciences, and neuropathological findings are placed within the context of a broader diagnosti...
Movement Disorders 4, the newest volume in the Blue Books in Neurology series provides you with rapid access to practical, clinical guidance on the diagnosis and pharmacologic treatment on the full range of movement disorders. Emphasizes the vast array of pharmacologic therapeutics, backed by clinical trials of the past 15 years to help you determine the best and most up-to-date drug therapy. Provides the latest on hot topics such as frontotemporal dementia and Tourette’s and related disorders, keeping you up to date on today’s issues. Presents the surgical management of Parkinson’s Disease to help you determine when to recommend surgery and for which patients. Includes extensive comprehensive information on Parkinson’s so you can better diagnose and treat PD patients. Offers more clinical details on tremors, differentiating between PD and other movement disorders and the genetics of movement disorders so you can determine which movement disorder is present.
This brand-new text provides you with an easy-to-use, comprehensive reference that features a clinical perspective balanced with relevant basic science. Inside, you'll find discussions of the latest research and how it has led to a greater understanding of the cause of disease, as well as burgeoning tests and the latest therapeutic agents available. From Alzheimer's disease to vestibular system disorders, you'll find the practical guidance you need to diagnose effectively and provide an appropriate therapeutic approach for each individual case. Plus, a templated, four-color design offers you easy access to pertinent information Integrates basic science with clinical neurology to help you better understand neurologic diseases and provide the most accurate diagnosis and best treatment plan for each patient. Discusses the latest research results and offers new information on treatment options. Features the expertise of international authorities, providing a worldwide perspective. Uses a templated, four-color format that makes information accessible and easy to understand—particularly the basic science concepts.
Winner of the BMA 2011 book awards: psychiatry category Winner of the Australian Journal of Ageing book of the year award This definitive work on dementia and related disorders has been fully updated and revised to reflect recent advances in this fast-moving field. The incidence of dementia continues to rise as the population of the world ages, and the condition represents one of the most significant challenges facing societies and health professionals in the next half-century. In this, the most comprehensive single volume work available on the subject, the editors have met this challenge by assembling a team of the world's leading experts on all aspects of the condition, from history, epidemiology and social aspects to the latest neurobiological research and advanced therapeutic strategies.
Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer’s Disease (AD). This book summarizes current knowledge of the Abeta peptide and its role in AD. Written by specialists in this fast moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta.
A directory to the universities of the Commonwealth and the handbook of their association.
When confronted with a neurological or psychiatric disorder in an elderly individual, a clinician or researcher is likely to ask how the processes of ageing have influenced the aetiology and presentation of the disorder, and will impact on its efficient management. There are many urban myths about ageing, and some of these apply to the brain. The reviews included in this book are an attempt to flush out some of these myths, and arm the clinician and general researcher with the empirical facts that can be mustered to substantiate claims about ageing. There are many salient questions: is cognitive change to be expected in an elderly individual? Is this change progressive, relentless and unsele...