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Melatonin
Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the integrative molecular mechanisms of the organism, based on interconnections of the regulatory systems: neural, endocrine, immune, and genetic, conveying into the uniqueness of human architecture. This book provides a systematic and updated overview of melatonin biochemical mechanisms of action, pharmacological features, and clinical uses, clutching the subject with complete details of pharmaceutical formulations designed for different routes of administration and different health issues, aiming at optimal melatonin bioavailability when therapeutically delivered. The book addresses a broad range of audiences, from healthcare professionals, medically and pharmaceutically based, to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge of the physiological and pathological implications of melatonin and its metabolites.
Early-life Environmental Exposure and Disease
This book offers valuable insights into the latest concepts and findings from epidemiologic, clinical and basic studies in the burgeoning area of early-life environmental exposure and diseases. The book is divided into five parts, starting with an overview of environmental exposure measurement and evaluation, followed by a review of the effects of exposure to various substances like tobacco smoke, pesticides and metals as well as stress on offspring’s health. It then discusses the developmental origins of a range of childhood diseases that affect growth, neural development and the immune system, and highlights the importance of longitudinal studies that measure exposure at potentially sensitive time points during childhood. It also provides up-to-date evidence of the intergenerational/transgenerational effects of early-life environmental exposure, especially via genetic and epigenetic pathways. Allowing readers to gain a thorough understanding of the predominating aspects of early-life environmental exposure and diseases, the book also provides a basis for developing environmental and health policies that could have wide and long-term impacts on human health.
Hydrogeochemistry of Aquatic Ecosystems
Hydrogeochemistry of Aquatic Ecosystems Discover the geological foundation of global water supply, focusing on resource conservation and restoration Hydrogeochemistry explores the connections between the geology of a region and the chemical characteristics and quality of its water sources, including such factors as erosion, evaporation, and, increasingly, man-made activities. With the emergence of climate change as a major factor reshaping water quality and availability, the need to understand interactions between hydrochemistry and geology has never been greater. Hydrogeochemistry of Aquatic Ecosystems meets this need by offering foundational knowledge about the hydrochemistry of different ...
Deep Learning In Biology And Medicine
Biology, medicine and biochemistry have become data-centric fields for which Deep Learning methods are delivering groundbreaking results. Addressing high impact challenges, Deep Learning in Biology and Medicine provides an accessible and organic collection of Deep Learning essays on bioinformatics and medicine. It caters for a wide readership, ranging from machine learning practitioners and data scientists seeking methodological knowledge to address biomedical applications, to life science specialists in search of a gentle reference for advanced data analytics.With contributions from internationally renowned experts, the book covers foundational methodologies in a wide spectrum of life scien...
Pectins
This book deepens the study and knowledge on pectins, especially in the processes of extraction, purification, and characterization, in short its many and wide applications. Among the most prominent applications are the food, pharmaceutical, and other industries. The development of pectins has a very promising future with a marked annual increase and with a wide range of sources. As written above, this book will help its readers to expand their knowledge on this biopolymer with vast application in the industry worldwide.
Postoperative Care in Thoracic Surgery
This book offers a comprehensive, up-to-date overview of optimal postoperative care in patients who have undergone thoracic surgery and discusses challenging issues that are of interest not only in the context of thoracic surgery but also more generally within the fields of anesthesia, intensive care, and pain medicine. The coverage ranges, for example, from use of non-invasive ventilation, extracorporeal membrane oxygenation, and new monitoring devices to fluid management, pain control, and treatment of arrhythmias. A key feature of the book is the exceptionally attractive list of authors, who represent the most authoritative experts on the topics that they address. The approach is appropriately multidisciplinary, acknowledging that in many centers thoracic anesthetists are responsible for care during the postoperative period. This book is exceptional in being devoted solely to postoperative care in thoracic surgery, even though the difficulties involved in thoracic operations sometimes exceed those of cardiac surgery, especially in the postoperative period.
Retinal Pharmacotherapeutics
The use of pharmacotherapeutics in the management of retinal diseases is rapidly evolving, and a favorable therapy for the patient. Today anti-VEGF agents are used for a range of indications from inflammation-related choroidal neovascularization to macular edema secondary to retinal vein occlusion or diabetic retinopathy. Beyond VEGF, there is an array of target areas under investigation – not only for vascular pathologies such as age-related macular degeneration and diabetic eye disease, but also for degenerative, infectious and inflammatory retinal conditions. This publication discusses many aspects from basic research on the retina, to animal models for retinal drug delivery, retinal diseases that are amenable to pharmacotherapy and also drugs and mechanisms in retinal diseases. Anyone concerned with the management of retinal diseases - the general ophthalmologist and the retina specialist alike – will find this book indispensable reading.
Statistical Machine Translation
The dream of automatic language translation is now closer thanks to recent advances in the techniques that underpin statistical machine translation. This class-tested textbook from an active researcher in the field, provides a clear and careful introduction to the latest methods and explains how to build machine translation systems for any two languages. It introduces the subject's building blocks from linguistics and probability, then covers the major models for machine translation: word-based, phrase-based, and tree-based, as well as machine translation evaluation, language modeling, discriminative training and advanced methods to integrate linguistic annotation. The book also reports the latest research, presents the major outstanding challenges, and enables novices as well as experienced researchers to make novel contributions to this exciting area. Ideal for students at undergraduate and graduate level, or for anyone interested in the latest developments in machine translation.
Fluorescence Lifetime Imaging Ophthalmoscopy
This book focuses on the emerging non-invasive imaging technique of Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). FLIO reveals unique information on retinal diseases, ranging from age-related macular degeneration and vascular diseases to hereditary retinal dystrophies. Fluorescence lifetimes enable the evaluation of disease progression before irreversible structural changes occur. The image acquisition is suitable for diagnostic purposes and follow-up examinations to investigate the natural course of disease, and to monitor the effects of possible therapies. This book fills the gap between available literature and gives state-of-the-art guidance on the principles of the FLIO technique, image acquisition, and data analysis. Written by a team of expert leaders within this field, this book will be relevant for scientists and clinicians with an interest in ophthalmoscopy.
Pediatric Cataract
This volume presents the latest trends in the management of pediatric cataract. It covers everything from the role of genetic and systemic work-up to the state of the art in surgery. Discussions include ocular modifications after surgery, the incidence and risk factors of post-surgery complications, and the management of complex cases. There is a chapter dedicated to post-aphakic glaucoma, a new insight to visual rehabilitation, and a summary of a recently published Delphi project. Pediatric ophthalmologists looking for the latest research in the management of cataract will find this publication to be invaluable reading. It will also be useful to general ophthalmologists, residents, and fellows, as well as to medical students and pediatricians who seek an update for daily clinical practice.
