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Lectins
A characteristic property of most, or perhaps all, proteins is their ability to combine specifically and reversibly with various substances. Well known examples are enzymes that bind substrates and inhibitors, and antibodies that bind antigens. This book deals with lectins, a class of proteins that bind carbohydrates. Another characteristic property of lectins is that they agglutinate cells or precipitate polysaccharides and glycoproteins. This is because lectins are polyvalent, i.e. each lectin molecule has at least two carbohydrate binding sites to allow crosslinking between cells (by combining with sugars on their surfaces) or between sugar containing macromolecules. The agglutinating and...
DNA Methylation, Epigenetics and Metastasis
This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.
As Light Before Dawn
As Light Before Dawn explores the mystical thought of Isaac ben Samuel of Akko, a major medieval kabbalist whose work has until now received relatively little attention. Through consideration of an extensive literary corpus, including much that still remains in manuscript, this study examines an array of themes and questions that have great applicability to the comparative study of mysticism and the broader study of religion. These include prayer and the nature of mystical experience; meditative concentration directed to God; and the power of mental intention, authority, creativity, and the transmission of wisdom.
Education in Africa
None
The Gambia Colony and Protectorate
The Gambia Colony and Protectorate (1967) provides both a history of the colony and a wealth of valuable practical and statistical information about its establishment and running. It provides a clear insight into the way that Britain’s colonies were governed and administered.
Human and Mammalian Cytogenetics
The history of science is mostly written retrospec tively, a generation or two after the actual events being discussed. Science historians are now analyzing and evaluating the origins of evolutionary and genetical theory in the nineteenth century and a sort of "Darwin industry" seems to have grown up. A history of mammalian cytogenetics by one of the main participants is, hence, a very welcome change, since it has a vividness, an immediacy and a personal flavor which these scholarly tomes and the official biog raphies of scientists mostly lack. The life of the author, Chinese-born, T. C. Hsu, has been a romantic and color ful one, and he is himself a unique personality, so that his book is a very unusual blend of reminiscences, history of his special field (which has transformed human genetics) and wise comments on the mistakes made along the way. The best qualities of a very fine Chinese mind have contributed to Dr. Hsu's career, including this book. Those qualities (which seem to me especially Chinese) include a kind of transparent honesty, a very direct em pirical approach to problems and superb technical ability.
Hybrid Forms of Peace
This book examines the role of everyday action in accepting, resisting and reshaping interventions, and the unique forms of peace that emerge from the interactions between local and international actors. Building on critiques of liberal peace-building, it redefines critical peace and conflict studies, based on new research from 16 countries.
Doing Business in 2004
A co-publication of the World Bank, International Finance Corporation and Oxford University Press
War 2.0
Examines the relevance of the changes in the media environment for the conduct of armed conflict and war, particularly as it relates to irregular warfare. Argues that new media provide an advantage to unconventional forces and discusses the reactions that regular forces should have in order to temper this advantage.
