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Restenosis remains the Achilles heel of Percutaneous Coronary Interventions. Numerous pharmacological agents have been tested in order to reduce acute thrombosis and the hyperproliferative cellular response, and drug eluting stents-using the stent as a platform for local drug delivery-are now considered a significant breakthrough in interventional cardiology. Pioneers in the field, the editors of Local Drug Delivery for Coronary Artery Disease have assembled an excellent team of contributors who offer their experience with threatened vessel closure and restenosis, acute thrombosis, hyperproliferative cellular response, stents and local drug delivery. They share their expertise on all aspects of the field, including a discussion of results from preclinical and clinical studies, and they examine alternative methods of molecular delivery to the vessel wall. With coverage of the most current methods and applications, as well as a host of photographs illustrating their implementation, this book will serve as an excellent reference for cardiologists, pharmacologists, cardiac surgeons, and trainees.
"This is a Ph.D. dissertation. Role of Inflammation in the Pathogenesis of Restenosis, Local Drug Delivery Using Drug Eluting Stents, In Vitro Stent Implantation, Optimization of Local Methylprednisolone Delivery to Inhibit Inflammatory Reaction and Neointimal Hyperplasia of Coated Coronary Stents, Cytochalasin Polymer Coated Stents Reduce Neointimal Formation in a Porcine Coronary Model, Long-Term Biocompatibility Evaluation of a Biodegradable Polymer Coated Stent in a Porcine Coronary Stent Model, Methotrexate Loaded SAE-Coated Coronary Stents Reduce Neointimal Hyperplasia in a Porcine Coronary Model, Local Methylprednisolone Delivery Using a Biodivysio Phosphorycholone Coated Drug Delivery Stents Reduces Inflammation and Neointimal Hyperplasia in a Porcine Coronary Stent Model, Stent Based Dexamethasone Delivery: From Pre-Clinical Data to the Stride Trial, General Discussions and Conclusions."
Performing any diagnostic test in medicine is always a matter of trying to get the condition of the patient diagnosed properly with the least effort, exposure, discomfort and at the same time with the lowest possible error probability. Pre-test probability is helpful but often imprecise, effectively overestimating the patient's risk profile. In a broader prevention objective, the phases of a disease, its onset, progression, and complications must be taken into account. The negative predictive value, which is so important, has in turn its main limitation in identifying the healthy patient, that is, the one who does not belong to any cluster of patients in which we would act in terms of preven...
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Describes technical advances in ambulatory blood pressure recording, including the move from invasive to noninvasive methods, and highlights the clinical utility of this modality - in identifying and assessing cardiovascular risk factors, monitoring labile hypertension and more.